Effects of the New Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m on High Glucose Induced Prolongation of Cardiac QT Interval and Increase of Coronary Perfusion Pressure

Figure 4

(a) MnSOD expression in hearts perfused with glucose 11.1 mM (control); glucose 11.1 mM + DMSO 1% (vehicle); glucose 33.3 mM (high glu); high glu + BF-5m (0.01, 0.05, and 0.1 μM); high glu + BF-5m (0.1 μM) + EX527 (10 mg/kg/day i.p.). (b) eNOS expression levels in hearts perfused as in panel (a). Results are derived from western blotting (panel (c) representative) and expressed as densitometric units; (d) tissue sorbitol content (μg/mL). Mean ± s.e.m. of observations for each group. Significant differences versus control are reported as and ; significant differences versus high glu are reported as and ; significant differences versus high glu + BF-5m 0.1 μM are reported as .

(a)

(b)

(c)

(d)