Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice

Table 1

Ingenuity pathways in kidney affected by OVE diabetes and/or OVE-ACKR2 diabetes.

Ingenuity canonical pathway	OVE versus FVB		OVE-ACKR2 versus FVB
	value	Ratio	value	Ratio
Diseases-specific pathways
Hepatic fibrosis		26/147	0.003	6/147
Atherosclerosis signaling		23/129	NS	2/129
Altered T cell and B cell signaling in rheumatoid arthritis		17/92	NS	1/92
Graft-versus-host disease signaling		10/50	NS	1/50
Glioma invasiveness signaling		12/60	NS	1/60
Cellular immune response
Communication between innate and adaptive immune cells		18/109	NS	1/109
Dendritic cell maturation		23/185	NS	0
Altered T cell and B cell signaling in rheumatoid arthritis		17/92	NS	1/92
Pattern recognition receptors of bacteria and viruses		19/106	NS	2/106
Leukocyte extravasation signaling		27/199	NS	2/199
Humoral immune response
Complement system		13/35	NS	1/35
B cell development		8/36	NS	0
NF-κB signaling		19/175	NS	0
p38 MAPK signaling		14/106	NS	0
Antigen presentation pathway		7/40	NS	0
Intracellular and second messenger signaling
p38 MAPK signaling		14/106	NS	0
Role of NFAT in regulation of the immune response		16/198	NS	0
Nitrogen metabolism		6/120	NS	1/120
Histidine metabolism		7/112	0.00012	5/112
Arginine and proline metabolism		8/176	0.00676	4/176
Cellular stress and injury
Intrinsic prothrombin activation pathway		8/32	NS	1/32
Coagulation system		9/38	NS	0
Extrinsic prothrombin activation pathway		6/20	NS	0
p38 MAPK signaling		14/106	NS	0
HMGB1 signaling		11/100	NS	0
Cytokine signaling
Dendritic cell maturation		23/185	NS	0
Acute phase response signaling		25/177	0.00813	6/177
TREM1 signaling		10/66	NS	0
IL-8 signaling		20/193	NS	2/193
NF-κB signaling		19/175	NS	0
Pathogen-influenced signaling
Dendritic cell maturation		23/185	NS	0
Pattern recognition receptors of bacteria and viruses		19/106	NS	2/106
Virus entry via endocytic pathways	0.00014	13/100	NS	2/100
Clathrin-mediated endocytosis signaling	0.00019	20/195	NS	2/195
Caveolar-mediated endocytosis signaling	0.0015	10/85	NS	1/85
Nuclear receptor signaling
LXR/RXR activation		28/136	0.0002	7/136
TR/RXR activation	0.0017	11/96	NS	2/96
Aryl hydrocarbon receptor signaling	0.0028	14/159	NS	6/159
Nitrogen metabolism	0.0037	6/120	NS	1/120
LPS/IL-1 mediated inhibition of RXR function	0.0039	18/235	NS	9/235

Ratio: RNAs altered versus FVB divided by the number of genes in the pathway. NS, not significant.