Journal of Diabetes Research / 2016 / Article / Tab 1

Review Article

The Stricter the Better? The Relationship between Targeted HbA1c Values and Metabolic Control of Pediatric Type 1 Diabetes Mellitus

Table 1

Univariate and multivariate linear model results for HbA values regarding HbA guideline groups (6.5% and 7.5%) and the other covariates. NA means not applied.

VariableGroupsNumber of studies
included in analysis
value from
univariate analysis
value from multivariate
analysis with parameter (95% CI)
The effect on
HbA level

HbA targeted levels6.5 (48 mmol/mol) versus 7.5 (58 mmol/mol)970.028<0.001
(−0.40, −0.12)
Lower in “6.5% (48 mmol/mol) countries”

Publication typeArticle versus abstract970.967NANA

HypoglycemiaMore versus less frequent300.427NANA

Diabetic ketoacidosisMore versus less frequent260.261NANA

Type of therapyMDI versus CSII560.249NANA

Study designFive groups970.356NANA

LocationEurope versus USA820.022NALower in Europe

GDP per capita ($)Continuous variable970.127NANA

Number of patients in the studyContinuous variable970.985NANA

Mean age in the study (years)Continuous variable930.0160.001
(0.12, 0.47)
Positive correlation ()

Mean duration of DM in the study (years)Continuous variable850.0370.753
(−0.20, −0.15)
Positive correlation ()

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