CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance
Table 4
Comparisons of body fat measurements and lipid profile between CCL2 G-2518A and CCR2 Val64Ile phenotype carriers.
Measurements
CCL2 G-2518A
CCR2 Val64Ile
Phenotype A+
Phenotype A−
Phenotype Ile+
Phenotype Ile−
(%)
301 (79)
79 (21)
140 (37)
240 (63)
Weight (kg)
72.0 ± 15.55
72.8 ± 13.56
NS
73.2 ± 14.82
71.5 ± 15.32
NS
BMI (kg/m2)
25.9 (22.9–29.1)
27.5 (24.3–29.65)
27.3 (23.8–29.7)
25.4 (23.0–28.9)
Total body fat (%)
29.6 ± 9.81
31.7 ± 8.57
NS
31.2 ± 9.05
29.4 ± 9.85
NS
BFR (kg/m2)
7.31 (5.24–9.92)
8.25 (6.24–11.40)
7.63 (5.57–10.90)
7.37 (5.31–9.93)
NS
Waist circumference (cm)
88.0 (78.4–98.0)
89.4 (79.3–96.5)
NS
89.1 (79.5–99.0)
88.1 (78.3–97.6)
NS
Glucose (mg/dL)
92 ± 12
93 ± 14
NS
95 ± 13
91 ± 12
Triglycerides (mg/dL)
142 ± 85.6
146 ± 94.2
NS
156 ± 8.5
135 ± 5.0
Total cholesterol (mg/dL)
181 ± 40.1
185 ± 34.3
NS
190 ± 43.7
180 ± 35.5
HDLc (mg/dL)
39 ± 14.8
37 ± 15.8
NS
38 ± 13.6
38 ± 15.8
NS
LDLc (mg/dL)
111 ± 35.6
109 ± 30.4
NS
114 ± 39.1
108 ± 31.2
NS
VLDLc (mg/dL)
28 ± 16.9
29 ± 18.8
NS
31 ± 20.1
26 ± 15.3
Apo-A1 (mg/dL)
114 ± 25.1
121 ± 29.1
NS
117 ± 24.4
114 ± 27.1
NS
Apo-B (mg/dL)
112 ± 30.0
121 ± 41.5
NS
119 ± 36.8
109 ± 27.8
. BMI: body mass index; BFR: body fat ratio; HDLc, LDLc, and VLDLc: high, low, and very low density lipoprotein cholesterol, respectively; Apo: apolipoprotein. A− or Ile−: wild-type phenotypes; polymorphic A+ phenotype (A/A plus G/A genotypes); polymorphic Ile+ phenotype (Ile/Ile plus Val/Ile genotypes). Data are presented as mean ± standard deviation and median (25–75 percentiles). Student’s -test and Mann-Whitney test with significantly, comparing the polymorphic phenotype carriers versus wild-type phenotypes carriers.
