A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies

Figure 6

Histomorphometric analysis of reepithelialization of standardized skin wounds in nondiabetic control (NDC) and diabetic rats treated with vehicle (D) or with a 1% or 3% CMC2.24 topically applied (D + 1% 2.24 or D + 3% 2.24, resp.) or with 30 mg/kg CMC2.24 administered systemically by oral intubation (D + 30 mg 2.24). Each value (%) represents the mean closure of the epithelium, assessed histologically, for 12 histological slices per group ± SEM, and the letters, A–E, assign statistically significant differences between the experimental groups. The star () symbol represents the numbers of wounds per group showing complete reepithelization on day 7.