Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2016, Article ID 5782904, 11 pages
http://dx.doi.org/10.1155/2016/5782904
Research Article

A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies

1Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA
2Department of Cariology and Comprehensive Care, College of Dentistry, New York University, New York, NY 10010, USA
3Departments of Dermatology and Emergency Medicine, Stony Brook University, Stony Brook, NY 11794, USA
4Department of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA
5Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA

Received 16 December 2015; Revised 10 February 2016; Accepted 2 March 2016

Academic Editor: Toshiyasu Sasaoka

Copyright © 2016 Yazhou Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Singer and R. A. F. Clark, “Cutaneous wound healing,” The New England Journal of Medicine, vol. 341, no. 10, pp. 738–746, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. L. J. Freeman, G. A. Hegreberg, and J. D. Robinette, “Cutaneous wound healing in Ehlers-Danlos syndrome,” Veterinary Surgery, vol. 18, no. 2, pp. 88–96, 1989. View at Google Scholar · View at Scopus
  3. B. A. Lipsky, “Evidence-based antibiotic therapy of diabetic foot infections,” FEMS Immunology and Medical Microbiology, vol. 26, no. 3-4, pp. 267–276, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Deresinski, “Infections in the diabetic patient: strategies for the clinician,” Infectious Disease Reports, vol. 91, no. 1, pp. 1–12, 1995. View at Google Scholar
  5. J. Stechmiller, L. Cowan, and G. Schultz, “The role of doxycycline as a matrix metalloproteinase inhibitor for the treatment of chronic wounds,” Biological Research for Nursing, vol. 11, no. 4, pp. 336–344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. L. M. Golub, N. S. Ramamurthy, T. F. McNamara, R. A. Greenwald, and B. R. Rifkin, “Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs,” Critical Reviews in Oral Biology and Medicine, vol. 2, no. 3, pp. 297–321, 1991. View at Google Scholar · View at Scopus
  7. L. M. Golub, H. M. Lee, M. E. Ryan, W. V. Giannobile, J. Payne, and T. Sorsa, “Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms,” Advances in Dental Research, vol. 12, no. 2, pp. 12–26, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. N. S. Ramamurthy, S. A. McClain, E. Pirila et al., “Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis,” Annals of the New York Academy of Sciences, vol. 878, pp. 720–723, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. N. S. Ramamurthy, A. J. Kucine, S. A. McClain, T. F. McNamara, and L. M. Golub, “Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin,” Advances in Dental Research, vol. 12, no. 2, pp. 144–148, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. H. D. Perry, L. W. Hodes, J. A. Seedor, E. D. Donnenfeld, T. F. McNamara, and L. M. Golub, “Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations,” Cornea, vol. 12, no. 5, pp. 379–382, 1993. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Seedor, H. D. Perry, T. F. McNamara, L. M. Golub, D. F. Buxton, and D. S. Guthrie, “Systemic tetracycline treatment of alkali-induced corneal ulceration in rabbits,” Archives of Ophthalmology, vol. 105, no. 2, pp. 268–271, 1987. View at Publisher · View at Google Scholar · View at Scopus
  12. H. D. Perry and L. M. Golub, “Systemic tetracyclines in the treatment of noninfected corneal ulcers: a case report and proposed new mechanism of action,” Annals of Ophthalmology, vol. 17, no. 12, pp. 742–744, 1985. View at Google Scholar · View at Scopus
  13. E. Katzap, M. J. Goldstein, N. V. Shah et al., “The chondroprotective properties of curcumin (Curcuma longa) and curcumin derived polyenolic zinc binding inhibitors against IL-1β and OsM-induced chrondrolysis,” Transactions of the Orthopedic Research Society, vol. 36, 2011. View at Google Scholar
  14. Y. Zhang, L. M. Golub, F. Johnson, and A. Wishnia, “PKa, Zinc- and serum albumin-binding of curcumin and two novel biologically-active chemically-modified curcumins,” Current Medicinal Chemistry, vol. 19, no. 25, pp. 4367–4375, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Zhang, Y. Gu, H.-M. Lee et al., “Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins,” Current Medicinal Chemistry, vol. 19, no. 25, pp. 4348–4358, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. M. S. Elburki, C. Rossa, M. R. Guimaraes et al., “A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations,” Mediators of Inflammation, vol. 2014, Article ID 959471, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. G. K. Reddy and C. S. Enwemeka, “A simplified method for the analysis of hydroxyproline in biological tissues,” Clinical Biochemistry, vol. 29, no. 3, pp. 225–229, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Blumenkrantz and G. Asboe-Hansen, “An assay for hydroxyproline and proline on one sample and a simplified method for hydroxyproline,” Analytical Biochemistry, vol. 63, no. 2, pp. 331–340, 1975. View at Publisher · View at Google Scholar · View at Scopus
  19. N. S. Ramamurthy, S. A. McClain, E. Pirila et al., “Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis,” Annals of the New York Academy of Sciences, vol. 878, no. 30, pp. 720–723, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Stamenkovic, “Extracellular matrix remodelling: the role of matrix metalloproteinases,” Journal of Pathology, vol. 200, no. 4, pp. 448–464, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. T. H. Vu and Z. Werb, “Matrix metalloproteinases: effectors of development and normal physiology,” Genes and Development, vol. 14, no. 17, pp. 2123–2133, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Sorsa, L. Tjäderhane, Y. T. Konttinen et al., “Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation,” Annals of Medicine, vol. 38, no. 5, pp. 306–321, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. L. A. Neuhold, L. Killar, W. Zhao et al., “Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice,” Journal of Clinical Investigation, vol. 107, no. 1, pp. 35–44, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Basset, A. Okada, M.-P. Chenard et al., “Matrix metalloproteinases as stromal effecters of human carcinoma progression: therapeutic implications,” Matrix Biology, vol. 15, no. 8-9, pp. 535–541, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. G. A. Chin, T. G. Thigpin, K. J. Perrin, L. L. Moldawer, and G. S. Schultz, “Treatment of chronic ulcers in diabetic patients with a topical metalloproteinase inhibitor, doxycycline,” Wounds, vol. 15, no. 10, pp. 315–323, 2003. View at Google Scholar · View at Scopus
  26. B. K. Pilcher, M. Wang, X.-J. Qin, W. C. Parks, R. M. Senior, and H. G. Welgus, “Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity,” Annals of the New York Academy of Sciences, vol. 878, pp. 12–24, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Yu, N. S. Ramamurthy, M. Leung, K. M. Chang, T. F. McNamara, and L. M. Golub, “Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study,” Journal of Periodontal Research, vol. 28, no. 6 I, pp. 420–428, 1993. View at Google Scholar · View at Scopus
  28. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, and H. Lehnert, “Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients,” Diabetologia, vol. 45, no. 7, pp. 1011–1016, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Gutiérrez-Fernández, M. Inada, M. Balbín et al., “Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8),” The FASEB Journal, vol. 21, no. 10, pp. 2580–2591, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Mani, G. S. Sidhu, R. Kumari, J. P. Gaddipati, P. Seth, and R. K. Maheshwari, “Curcumin differentially regulates TGF-β1, its receptors and nitric oxide synthase during impaired wound healing,” BioFactors, vol. 16, no. 1-2, pp. 29–43, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. G. S. Sidhu, H. Mani, J. P. Gaddipati et al., “Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice,” Wound Repair and Regeneration, vol. 7, no. 5, pp. 362–374, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. M. S. Elburki, D. D. Moore, N. G. Terezakis et al., “A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: periodontal and systemic effects,” Journal of Periodontal Research, 2016. View at Publisher · View at Google Scholar
  33. M. Panchatcharam, S. Miriyala, V. S. Gayathri, and L. Suguna, “Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species,” Molecular and Cellular Biochemistry, vol. 290, no. 1-2, pp. 87–96, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. S. E. Gill and W. C. Parks, “Metalloproteinases and their inhibitors: regulators of wound healing,” International Journal of Biochemistry and Cell Biology, vol. 40, no. 6-7, pp. 1334–1347, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. L. M. Golub, P. R. Garant, and N. S. Ramamurthy, “Inflammatory changes in gingival collagen in the alloxan-diabetic rat,” Journal of Periodontal Research, vol. 12, no. 5, pp. 402–418, 1977. View at Publisher · View at Google Scholar · View at Scopus
  36. L. M. Golub, R. A. Greenwald, E. J. Zebrowski, and N. S. Ramamurthy, “The effect of experimental diabetes on the molecular characteristics of rat tail tendon collagen,” Biochimica et Biophysica Acta, vol. 534, pp. 73–81, 1978. View at Google Scholar
  37. C. N. Serhan, S. D. Brain, C. D. Buckley et al., “Resolution of inflammation: state of the art, definitions and terms,” The FASEB Journal, vol. 21, no. 2, pp. 325–332, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Gu, H. M. Lee, H. Wang et al., “A novel chemically-modified-curcumin (CMC2.24) resolves systemic inflammation in diabetic rats,” Journal of Dental Research, vol. 94, abstract #2249, 2015. View at Google Scholar
  39. M. Clemens, N. Napolitano, H. M. Lee et al., “Chemically modified curcumin normalizes chronic inflammation in diabetic rats,” Journal of Dental Research, vol. 91, abstract 1526, 2012. View at Google Scholar
  40. Y. Tang, M. J. Zhang, J. Hellmann, M. Kosuri, A. Bhatnagar, and M. Spite, “Proresolution therapy for the treatment of delayed healing of diabetic wounds,” Diabetes, vol. 62, no. 2, pp. 618–627, 2013. View at Publisher · View at Google Scholar · View at Scopus