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Journal of Diabetes Research
Volume 2016, Article ID 5807876, 8 pages
http://dx.doi.org/10.1155/2016/5807876
Research Article

In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications

1Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA
2Virginia Tech, Wake Forest University School of Biomedical Engineering and Sciences, 320 ICTAS, Stanger St., Virginia Tech, Blacksburg, VA 24060, USA

Received 19 August 2016; Revised 4 November 2016; Accepted 13 November 2016

Academic Editor: Hiroshi Okamoto

Copyright © 2016 Guoguang Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. W. Pagliuca, J. R. Millman, M. Gürtler et al., “Generation of functional human pancreatic β cells in vitro,” Cell, vol. 159, no. 2, pp. 428–439, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Zhou, D. L. Mack, J. K. Williams et al., “Genetic modification of primate amniotic fluid-derived stem cells produces pancreatic progenitor cells in vitro,” Cells Tissues Organs, vol. 197, no. 4, pp. 269–282, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Klein, “Hyperglycemia and microvascular and macrovascular disease in diabetes,” Diabetes Care, vol. 18, no. 2, pp. 258–268, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Tonelli, P. Muntner, A. Lloyd et al., “Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study,” The Lancet, vol. 380, no. 9844, pp. 807–814, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Khan, M. Y. Bertram, R. Jina, B. Mash, N. Levitt, and K. Hofman, “Preventing diabetes blindness: cost effectiveness of a screening programme using digital non-mydriatic fundus photography for diabetic retinopathy in a primary health care setting in South Africa,” Diabetes Research and Clinical Practice, vol. 101, no. 2, pp. 170–176, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. C. S. Fox, K. Matsushita, M. Woodward et al., “Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis,” The Lancet, vol. 380, no. 9854, pp. 1662–1673, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. N. C. Schaper, J. Apelqvist, and K. Bakker, “Reducing lower leg Amputations in diabetes: a challenge for patients, healthcare providers and the healthcare system,” Diabetologia, vol. 55, no. 7, pp. 1869–1872, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Hao, B. Tyrberg, P. Itkin-Ansari et al., “Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas,” Nature Medicine, vol. 12, no. 3, pp. 310–316, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. D. Bellin, F. B. Barton, A. Heitman et al., “Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes,” American Journal of Transplantation, vol. 12, no. 6, pp. 1576–1583, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. D.-S. Ham, J. Shin, J.-W. Kim, H.-S. Park, J.-H. Cho, and K.-H. Yoon, “Generation of functional insulin-producing cells from neonatal porcine liver-derived cells by PDX1/VP16, BETA2/NeuroD and MafA,” PLoS ONE, vol. 8, no. 11, Article ID e79076, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. H. A. Russ, Y. Bar, P. Ravassard, and S. Efrat, “In vitro proliferation of cells derived from adult human β-cells revealed by cell-lineage tracing,” Diabetes, vol. 57, no. 6, pp. 1575–1583, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. W. L. Suarez-Pinzon, J. R. T. Lakey, S. J. Brand, and A. Rabinovitch, “Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet β-cells from pancreatic duct cells and an increase in functional β-cell mass,” The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3401–3409, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Parnaud, D. Bosco, T. Berney et al., “Proliferation of sorted human and rat beta cells,” Diabetologia, vol. 51, no. 1, pp. 91–100, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Talchai, S. Xuan, H. V. Lin, L. Sussel, and D. Accili, “Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure,” Cell, vol. 150, no. 6, pp. 1223–1234, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. A. G. Kayali, L. E. Flores, A. D. Lopez et al., “Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing β-cells,” Diabetes, vol. 56, no. 3, pp. 703–708, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. C. Gershengorn, A. A. Hardikar, C. Wei, E. Ceras-Raaka, B. Marcus-Samuels, and B. M. Raaka, “Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells,” Science, vol. 306, no. 5705, pp. 2261–2264, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. K. L. Seeberger, S. J. Anderson, C. E. Ellis, T. Y. Yeung, and G. S. Korbutt, “Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium,” World Journal of Diabetes, vol. 5, no. 1, pp. 59–68, 2014. View at Publisher · View at Google Scholar
  18. B. Blum, A. N. Roose, O. Barrandon et al., “Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway,” eLife, vol. 3, Article ID e02809, 2014. View at Publisher · View at Google Scholar
  19. S. Hrvatin, C. W. O'Donnell, F. Deng et al., “Differentiated human stem cells resemble fetal, not adult, β cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 8, pp. 3038–3043, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. S. S. Dey, N. Yoshida, and K. Hasegawa, “Overview of pancreatic replacement of β-cells from various cell sources,” in Stem Cell Therapy for Organ Failure, pp. 181–193, Springer, Berlin, Germany, 2014. View at Google Scholar
  21. J. M. W. Slack, “Developmental biology of the pancreas,” Development, vol. 121, no. 6, pp. 1569–1580, 1995. View at Google Scholar · View at Scopus
  22. S. Bonner-Weir and G. C. Weir, “New sources of pancreatic β-cells,” Nature Biotechnology, vol. 23, no. 7, pp. 857–861, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. S.-H. Mirmalek-Sani, G. Orlando, J. P. McQuilling et al., “Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering,” Biomaterials, vol. 34, no. 22, pp. 5488–5495, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Zhang, W. Jiang, M. Liu et al., “Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells,” Cell Research, vol. 19, no. 4, pp. 429–438, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Tateishi, J. He, O. Taranova, G. Liang, A. C. D'Alessio, and Y. Zhang, “Generation of insulin-secreting islet-like clusters from human skin fibroblasts,” The Journal of Biological Chemistry, vol. 283, no. 46, pp. 31601–31607, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. C. N. Mayhew and J. M. Wells, “Converting human pluripotent stem cells into β-cells: recent advances and future challenges,” Current Opinion in Organ Transplantation, vol. 15, no. 1, pp. 54–60, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Hui, Y. G. Tang, L. Zhu et al., “Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells Via Hedgehog, cAMP, and PI3K pathways,” Pancreas, vol. 39, no. 3, pp. 315–322, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Chen, M. Borowiak, J. L. Fox et al., “A small molecule that directs differentiation of human ESCs into the pancreatic lineage,” Nature Chemical Biology, vol. 5, no. 4, pp. 258–265, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Borowiak, R. Maehr, S. Chen et al., “Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells,” Cell Stem Cell, vol. 4, no. 4, pp. 348–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Champeris Tsaniras and P. M. Jones, “Generating pancreatic β-cells from embryonic stem cells by manipulating signaling pathways,” Journal of Endocrinology, vol. 206, no. 1, pp. 13–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Ouziel-Yahalom, M. Zalzman, L. Anker-Kitai et al., “Expansion and redifferentiation of adult human pancreatic islet cells,” Biochemical and Biophysical Research Communications, vol. 341, no. 2, pp. 291–298, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. I. Rafiq, G. Da Silva Xavier, S. Hooper, and G. A. Rutter, “Glucose-stimulated preproinsulin gene expression and nuclear trans- location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2,” Journal of Biological Chemistry, vol. 275, no. 21, pp. 15977–15984, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. I. Rafiq, H. J. Kennedy, and G. A. Rutter, “Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells,” The Journal of Biological Chemistry, vol. 273, no. 36, pp. 23241–23247, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. G. C. Weir, C. Aguayo-Mazzucato, and S. Bonner-Weir, “β-cell dedifferentiation in diabetes is important, but what is it?” Islets, vol. 5, no. 5, pp. 233–237, 2013. View at Google Scholar
  35. M. Zalzman, L. Anker-Kitai, and S. Efrat, “Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype,” Diabetes, vol. 54, no. 9, pp. 2568–2575, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Racanicchi, G. Basta, P. Montanucci et al., “Neonatal pig liver-derived progenitors for insulin-producing cells: An In Vitro Study,” Tissue Engineering, vol. 13, no. 12, pp. 2923–2931, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. H. A. Russ, E. Sintov, L. Anker-Kitai et al., “Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro,” PLoS ONE, vol. 6, no. 9, Article ID e25566, 2011. View at Publisher · View at Google Scholar · View at Scopus