Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies

Figure 3

Age at detection of islet autoantibodies and immune reactivity to MAP, ZnT8, and PI homologous peptides in children at risk for T1D. Grey bars correspond to the time-point samples available for each child. : identity of children positive for the studied peptides or/and islet autoantibodies (); highlighted patients progressed to T1D at 5, 4, and 1,5 years of age, respectively; patient indicated in italics was lost during the follow-up.