Research Article

Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies

Figure 4

Distribution of anti-HP Abs levels measured by ELISA in T1D at-risk subjects and healthy controls. Sera of 23 ARS and 22 HCs were screened for Abs against J0I929_HELP (a) and T2T4W3_HELP (b). The dotted lines represent cut-off values calculated by ROC analysis and used to discriminate between positive and negative samples. Dashed lines indicate the respective mean OD values. Area under the curve (AUC) and values are reported in the top-right corners.
(a)
(b)