Noninvasive Tracking of Encapsulated Insulin Producing Cells Labelled with Magnetic Microspheres by Magnetic Resonance Imaging

Figure 3

Viability and insulin secretion of encapsulated MM-labelled cells. (a) Viability images of unlabelled and MM-labelled encapsulated MIN6 (i and iii) and human islets (ii and iv), respectively. Bar is 100 μm for (i) and (iii) and 200 μm for (ii) and (iv), respectively. (b) Viability of encapsulated MM-labelled cells cultured for varied time points after encapsulation. Values are mean ± SEM ( capsules for each time point); ns, for viabilities between unlabelled and MM-labelled MIN6 and human islets at each time point (Student’s t-test). (c) Glucose stimulated insulin secretion of both MM-labelled MIN6 (i) and human islets (ii) 24 hr after encapsulation. Values are mean ± SEM (); for basal versus stimulated insulin secretion for encapsulated unlabelled and MM-labelled MIN6, respectively (Student’s t-test).

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