Cdk5r1 Overexpression Induces Primary β-Cell Proliferation

Table 1

Cell cycle associated genes upregulated by Nr4a1 and Nr4a3 but not Nkx6.1. Genes upregulated by Nr4a1 and Nr4a3 that are not regulated by Nkx6.1 were selected based on changes greater than 1.5-fold and values less than 0.05. Genes were defined by the GO category cell cycle.

Gene name	Fold change	value	Process
Gas2	12.27	0.001577852	Cytokinesis
Tgfa	2.4	0.000103799	Growth factor
Rapgef5	2.31	0.004103808	Ras activator
Nuf2	2.24	0.002117132	Centromere
Chl1	2.17	0.023016307	G2/M transition
Top2a	2.04	0.002104745	DNA replication
Cks2	1.92	0.007478331	CDK regulation
Gins4	1.87	0.003569736	DNA replication
Aspm	1.83	0.004862977	Spindle formation
Cdk5r1	1.78	0.00289215	CDK regulation
Prc1	1.75	0.005448853	Cytokinesis
Kif2c	1.75	0.000350709	Centromere
Dscc1	1.73	0.008438809	DNA replication
Kif15	1.66	0.008896449	Microtubules
Ncapd2	1.65	0.004007301	DNA condensation
Prim1	1.58	0.001821116	DNA replication