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Journal of Diabetes Research
Volume 2016 (2016), Article ID 6741745, 6 pages
http://dx.doi.org/10.1155/2016/6741745
Research Article

HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia

1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China

Received 9 July 2015; Accepted 6 August 2015

Academic Editor: Bernard Portha

Copyright © 2016 Hai-Yan Qiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. E. Curran, I. Splawski, K. W. Timothy, G. M. Vincent, E. D. Green, and M. T. Keating, “A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome,” Cell, vol. 80, no. 5, pp. 795–803, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. A. B. Hardy, J. E. M. Fox, P. R. Giglou et al., “Characterization of Erg K+ channels in α- and β-cells of mouse and human islets,” The Journal of Biological Chemistry, vol. 284, no. 44, pp. 30441–30452, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Lodise, J. Graves, C. Miller, J. F. Mohr, B. Lomaestro, and R. P. Smith, “Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients,” Pharmacotherapy, vol. 27, no. 11, pp. 1498–1505, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. K. J. Tack and J. A. Smith, “The safety profile of ofloxacin,” The American Journal of Medicine, vol. 87, no. 6, pp. 78S–81S, 1989. View at Google Scholar · View at Scopus
  5. L. V. Friedrich and R. Dougherty, “Fatal hypoglycemia associated with levofloxacin,” Pharmacotherapy, vol. 24, no. 12, pp. 1807–1812, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Saraya, M. Yokokura, T. Gonoi, and S. Seino, “Effects of fluoroquinolones on insulin secretion and β-cell ATP-sensitive K+ channels,” European Journal of Pharmacology, vol. 497, no. 1, pp. 111–117, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Tomita, M. Onishi, E. Sato, Y. Kimura, and K. Kihira, “Gatifloxacin induces augmented insulin release and intracellular insulin depletion of pancreatic islet cells,” Biological & Pharmaceutical Bulletin, vol. 30, no. 4, pp. 644–647, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. A. F. Spigelman, X. Dai, and P. E. MacDonald, “Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans,” Diabetologia, vol. 53, no. 9, pp. 1917–1926, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Yan, D. J. Figueroa, C. P. Austin et al., “Expression of voltage-gated potassium channels in human and rhesus pancreatic islets,” Diabetes, vol. 53, no. 3, pp. 597–607, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Barg, “Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells,” Pharmacology & Toxicology, vol. 92, no. 1, pp. 3–13, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Su, H. Yu, N. Lenka, J. Hescheler, and S. Ullrich, “The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1,” Pflugers Archiv, vol. 442, no. 1, pp. 49–56, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Rosati, P. Marchetti, O. Crociani et al., “Glucose- and arginine-induced insulin secretion by human pancreatic bta-cells: the role of HERG K+ channels in firing and release,” The FASEB Journal, vol. 14, no. 15, pp. 2601–2610, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Mühlbauer, I. Bazwinsky, S. Wolgast, A. Klemenz, and E. Peschke, “Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell,” Cellular and Molecular Life Sciences, vol. 64, no. 6, pp. 768–780, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. B. J. Zünkler, S. Claaßen, M. Wos-Maganga, I. Rustenbeck, and U. Holzgrabe, “Effects of fluoroquinolones on HERG channels and on pancreatic β-cell ATP-sensitive K+ channels,” Toxicology, vol. 228, no. 2-3, pp. 239–248, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Ghaly, C. Kriete, S. Sahin et al., “The insulinotropic effect of fluoroquinolones,” Biochemical Pharmacology, vol. 77, no. 6, pp. 1040–1052, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-W. Chou, J.-L. Wang, C.-H. Chang, J.-J. Lee, W.-Y. Shau, and M.-S. Lai, “Risk of severe dysglycemia among diabetic patients receiving levofloxacin, ciprofloxacin, or moxifloxacin in Taiwan,” Clinical Infectious Diseases, vol. 57, no. 7, pp. 971–980, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. W. K. Kabbara, W. H. Ramadan, P. Rahbany, and S. Al-Natour, “Evaluation of the appropriate use of commonly prescribed fluoroquinolones and the risk of dysglycemia,” Therapeutics and Clinical Risk Management, vol. 11, pp. 639–647, 2015. View at Publisher · View at Google Scholar
  18. Y. Ishiwata, Y. Takahashi, M. Nagata, and M. Yasuhara, “Effects of moxifloxacin on serum glucose concentrations in rats,” Biological & Pharmaceutical Bulletin, vol. 36, no. 4, pp. 686–690, 2013. View at Publisher · View at Google Scholar · View at Scopus