Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice

Table 2

Differentially expressed genes from adipogenesis pathway of Id2−/− mice. Genes with significant differences () are shown in bold.

Adipogenesis array	Symbol	Refseq	All		Male		Female		Clock control gene-peak phase
			Fold change	value	Fold change	value	Fold change	value
Gene name
Bone morphogenetic protein 4	Bmp4	NM_007554	1.6	0.04	1.7	0.12	1.6	0.01	—
Complement factor D (adipsin)	Cfd	NM_013459	2.5	0.02	4.3	0.03			—
Insulin receptor substrate 1	Irs1	NM_010570	1.2	0.03	1.1	0.29	1.4	0.02	—
TSC22 domain family, member 3	Tsc22d3	NM_010286	1.6	0.04	1.9	0.09			CT16
Axin 1	Axin1	NM_009733	−1.2	0.07	−1.3	0.05			—
Cyclin-dependent kinase 4	Cdk4	NM_009870	−1.4	0.003	−1.7	0.001			CT6
Delta-like 1 homolog (Drosophila)	Dlk1	NM_010052	−1.9	0.01	−2.2	0.01			—
Fatty acid synthase	Fasn	NM_007988	−1.2	0.06	−1.4	0.02			—
Lipase, hormone sensitive	Lipe	NM_010719	−1.2	0.06	−1.5	0.02			—
Nuclear receptor coactivator 2	Ncoa2	NM_008678	−1.2	0.07	−1.3	0.07			—
Peroxisome proliferator activated receptor alpha	Ppara	NM_011144	−2.1	0.01	−2.3	0.06	−1.7	0.09	CT6
Peroxisome proliferator activated receptor gamma	Pparg	NM_011146			−1.2	0.06
Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Ppargc1a; (PGC-1 )	NM_008904	−1.2	0.09			−1.5	0.004	CT8
Peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Ppargc1b; (PGC-1 )	NM_133249	−1.4	0.01	−1.4	0.04			CT5
PR domain containing 16	Prdm16	NM_027504	−1.3	0.03	−1.5	0.03			—
Twist homolog 1 (Drosophila)	Twist1	NM_011658	−1.8	0.01	−2.0	0.06	−1.5	0.04	—
Actin, beta	Actb	NM_007393	−1.2	0.02	−1.4	0.004			—