Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2"> </td><td align="center">ISCs-SN</td><td align="center">PSCs-SN</td></tr><tr class="thead"><td align="center">(MFI)</td><td align="center">(MFI)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Negative control</td><td align="center">5828.58</td><td align="center">6319.81</td></tr><tr><td align="left">Integrin alpha M beta 2</td><td align="center">88599.0</td><td align="center">75866.5</td></tr><tr><td align="left">IFN-gamma</td><td align="center">17506.0</td><td align="center">16974.0</td></tr><tr><td align="left">MCP-1</td><td align="center">17223.0</td><td align="center">24933.5</td></tr><tr><td align="left">MMP-2</td><td align="center">13303.0</td><td align="center">22384.5</td></tr><tr><td align="left">PDGF</td><td align="center">20689.0</td><td align="center">28034.5</td></tr><tr><td align="left">TNF-alpha</td><td align="center">17654.5</td><td align="center">24232.0</td></tr><tr><td align="left">TLR4</td><td align="center">69218.5</td><td align="center">48604.0</td></tr><tr><td align="left">TROY</td><td align="center">96330.0</td><td align="center">104265.0</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Cytokines were highly expressed in both ISC-SN and PSC-SN. ISCs-SN/PSC-SN was quantified by mean fluorescence intensity (MFI) using RayBio Biotin Label-Based Rat Antibody Array 1 assay. MFI ≥ 1.5-fold of negative control was considered as highly expressed.

Journal of Diabetes Research

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Table 2

Table 2: Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell 