Altered Macrophage and Dendritic Cell Response in Mif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes

Figure 2

Mif deficiency prevents the elevation of proinflammatory cytokine production. The levels of Mif (a), IL-12 (b), IFN-γ (c), IL-17 (d), IL-4 (e), and IL-13 (f) in the sera from Wt (■) and Mif−/− (▼) mice at 0, 2, 4, and 8 weeks after STZ administration were measured via enzyme-linked immunosorbent assay (ELISA) in triplicate, as indicated in Section 2. Data are expressed as the means ± SE (n = at least 5–7 mice per group/time point). , , or , GraphPad Prism software 6.

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