Altered Macrophage and Dendritic Cell Response in Mif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes

Figure 4

Kinetics of antibody responses in type 1 diabetes mellitus models induced by low-dose STZ. Specific production of IgG2a (a) and IgG1 (b) antipancreatic islet antigen antibodies. Sera from Wt (■) and Mif−/− mice (▼) at weeks 0, 2, 4, and 8 after STZ administration were processed by ELISA, using pancreatic islets antigen (PIAg) as the source of specific antigen as indicated in Section 2. Data are expressed as the mean reciprocal endpoint titer ± SEM. Five to six animals were analyzed in each group. The data shown are representative of one out of three identical experiments with similar results. Mann-Whitney U test. , , GraphPad Prism software 6.

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