Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes

Table 2

In this table, the representation of microRNA (miR), cardiac resynchronization therapy (CRT) effect on miRs expression, the miR’s epigenetic effect, and the potential role in heart remodelling is displayed. On the right column, the bibliography reference for every investigated miR is represented. IK1 is inward-rectifier K⁺ current; SREBP2 is sterol regulatory element-binding protein 2 (an oxidative stress-induced protein); PI3 is phosphoinositide 3-kinase; Akt is serine/threonine kinase; p53 is p53 protein.

Investigated miRNA	CRT effect	Epigenetic effect	Potential role in heart remodelling	Bibliography
miR-26b-5p	Significant increase	IK1 and Ca^2+ current	Membrane channel ionic currents	[25–27]
miR-29a-3p	Significant increase	Collagen, fibrillin, and elastin	Cardiac fibrosis	[25, 26, 28]
miR-30e-5p	Significant increase	Angiotensin II, cystathionine-γ-lyase (CyL), and hydrogen sulfide (HS)	Cardiac angiogenesis and cardiac apoptosis	[25, 26, 29]
miR-92a-3p	Significant increase	SREBP2 and angiotensin II	Cardiac angiogenesis	[25, 26, 30]
miR-145-5p	Significant increase	PI3 Kinase/Akt/p53	Cardiac angiogenesis	[25, 26, 31]