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Journal of Diabetes Research
Volume 2016 (2016), Article ID 7313162, 7 pages
http://dx.doi.org/10.1155/2016/7313162
Research Article

Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients

1Department of Clinical Chemistry, S. Jacopo Hospital, 51100 Pistoia, Italy
2Agenzia Regionale Sanità, Toscana, Florence, Italy
3Accademia Medica Pistoiese F. Pacini, 51100 Pistoia, Italy
4Diabetes Unit, S. Jacopo Hospital, 51100 Pistoia, Italy
5Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy

Received 5 November 2015; Revised 7 January 2016; Accepted 11 January 2016

Academic Editor: Ronald G. Tilton

Copyright © 2016 Zaleida Napoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Huxtable, “Physiological actions of taurine,” Physiological Reviews, vol. 72, no. 1, pp. 101–163, 1992. View at Google Scholar · View at Scopus
  2. S. W. Schaffer, T. Ito, and J. Azuma, “Clinical significance of taurine,” Amino Acids, vol. 46, no. 1, pp. 1–5, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Imae, T. Asano, and S. Murakami, “Potential role of taurine in the prevention of diabetes and metabolic syndrome,” Amino Acids, vol. 46, no. 1, pp. 81–88, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Ripps and W. Shen, “Review: taurine: a “very essential” amino acid,” Molecular Vision, vol. 18, pp. 2673–2686, 2012. View at Google Scholar · View at Scopus
  5. T. Ito, S. W. Schaffer, and J. Azuma, “The potential usefulness of taurine on diabetes mellitus and its complications,” Amino Acids, vol. 42, no. 5, pp. 1529–1539, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. K. C. Hayes, R. E. Carey, and S. Y. Schmidt, “Retinal degeneration associated with taurine deficiency in the cat,” Science, vol. 188, no. 4191, pp. 949–951, 1975. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Zeng, H. Xu, M. Mi et al., “Effects of taurine on glial cells apoptosis and taurine transporter expression in retina under diabetic conditions,” Neurochemical Research, vol. 35, no. 10, pp. 1566–1574, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. H. Hansen, “The role of taurine in diabetes and the development of diabetic complications,” Diabetes/Metabolism Research and Reviews, vol. 17, no. 5, pp. 330–346, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. S. Di Leo, S. A. Santini, S. Cercone et al., “Chronic taurine supplementation ameliorates oxidative stress and Na+ K+ ATPase impairment in the retina of diabetic rats,” Amino Acids, vol. 23, no. 4, pp. 401–406, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. A. S. Di Leo, G. Ghirlanda, N. Gentiloni Silveri, B. Giardina, F. Franconi, and S. A. Santini, “Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations,” Free Radical Research, vol. 37, no. 3, pp. 323–330, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. L. Tappaz, “Taurine biosynthetic enzymes and taurine transporter: molecular identification and regulations,” Neurochemical Research, vol. 29, no. 1, pp. 83–96, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Han, A. B. Patters, D. P. Jones, I. Zelikovic, and R. W. Chesney, “The taurine transporter: mechanisms of regulation,” Acta Physiologica, vol. 187, no. 1-2, pp. 61–73, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Franconi, M. Miceli, A. Fazzini et al., “Taurine and diabetes. Humans and experimental models,” in Taurine 2, vol. 403 of Advances in Experimental Medicine and Biology, pp. 579–582, Springer, New York, NY, USA, 1996. View at Publisher · View at Google Scholar
  14. F. Franconi, A. Loizzo, G. Ghirlanda, and G. Seghieri, “Taurine supplementation and diabetes mellitus,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 1, pp. 32–36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. J. W. Baynes and S. R. Thorpe, “Role of oxidative stress in diabetic complications: a new perspective on an old paradigm,” Diabetes, vol. 48, no. 1, pp. 1–9, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Bianchi, R. Lari, R. Anichini et al., “Taurine transporter gene expression in peripheral mononuclear blood cells of type 2 diabetic patients,” Amino Acids, vol. 42, no. 6, pp. 2267–2274, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Di Simplicio, L. A. De Giorgio, E. Cardaioli et al., “Glutathione, glutathione utitizing enzymes and thioltransferase in platetets of insulin-dependent diabetic patients: relation with platelet aggregation and with microangiopatic complications,” European Journal of Clinical Investigation, vol. 25, no. 9, pp. 665–669, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Campesi, A. Galistu, C. Carru, F. Franconi, M. Fois, and A. Zinellu, “Glutamyl cycle in the rat liver appears to be sex-gender specific,” Experimental and Toxicologic Pathology, vol. 65, no. 5, pp. 585–589, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Fagan, B. G. Sleczka, and I. Sohar, “Quantitation of oxidative damage to tissue proteins,” International Journal of Biochemistry and Cell Biology, vol. 31, no. 7, pp. 751–757, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Zinellu, S. Sotgia, M. F. Usai, G. Pintus, L. Deiana, and C. Carru, “Improved method for plasma ADMA, SDMA, and arginine quantification by field-amplified sample injection capillary electrophoresis UV detection,” Analytical and Bioanalytical Chemistry, vol. 399, no. 5, pp. 1815–1821, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Zinellu, S. Sotgia, S. Bastianina et al., “Taurine determination by capillary electrophoresis with laser-induced fluorescence detection: from clinical field to quality food applications,” Amino Acids, vol. 36, no. 1, pp. 35–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Zinellu, S. Sotgia, E. Pisanu et al., “Quantification of neurotransmitter amino acids by capillary electrophoresis laser-induced fluorescence detection in biological fluids,” Analytical and Bioanalytical Chemistry, vol. 398, no. 5, pp. 1973–1978, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. M. H. Anderson, A. Howard, J. R. F. Walters, V. Ganapathy, and D. T. Thwaites, “Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl-dependent TauT (SLC6A6),” Journal of Physiology, vol. 587, no. 4, pp. 731–744, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-Ct method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. R. Shi, L. Gao, S. H. Wang et al., “Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes,” Metabolism: Clinical and Experimental, vol. 52, no. 7, pp. 827–833, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. J. Stevens, Y. Hosaka, J. A. Masterson, S. M. Jones, T. P. Thomas, and D. D. Larkin, “Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells,” American Journal of Physiology—Endocrinology and Metabolism, vol. 277, no. 4, pp. E760–E771, 1999. View at Google Scholar · View at Scopus
  27. E. Nakashima, R. Pop-Busui, R. Towns et al., “Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase,” Antioxidants and Redox Signaling, vol. 7, no. 11-12, pp. 1530–1542, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Askwith, W. Zeng, M. C. Eggo, and M. J. Stevens, “Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 297, no. 3, pp. E620–E628, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Franconi, F. Bennardini, A. Mattana et al., “Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation,” The American Journal of Clinical Nutrition, vol. 61, no. 5, pp. 1115–1119, 1995. View at Google Scholar · View at Scopus
  30. I. C. Allen, A. Schousboe, and R. Griffiths, “Effect of l-homocysteine and derivatives on the high-affinity uptake of taurine and GABA into synaptosomes and cultured neurons and astrocytes,” Neurochemical Research, vol. 11, no. 11, pp. 1487–1496, 1986. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Chang, J. Xu, F. Yu, J. Zhao, X. Tang, and C. Tang, “Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats,” Amino Acids, vol. 27, no. 1, pp. 37–48, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. J. T. Brosnan and M. E. Brosnan, “The sulfur-containing amino acids: an overview,” Journal of Nutrition, vol. 136, no. 6, pp. 1636S–1640S, 2006. View at Google Scholar · View at Scopus
  33. H. Jiang, S. P. Stabler, R. H. Allen, S. H. Abman, and K. N. Maclean, “Altered hepatic sulfur metabolism in cystathionine β-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways,” The FASEB Journal, vol. 28, no. 9, pp. 4044–4054, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Zeng, H. Xu, M. Mi et al., “Dietary taurine supplementation prevents glial alterations in retina of diabetic rats,” Neurochemical Research, vol. 34, no. 2, pp. 244–254, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Vilchis and R. Salceda, “Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium,” Neurochemical Research, vol. 21, no. 10, pp. 1167–1171, 1996. View at Publisher · View at Google Scholar · View at Scopus