Topical Administration of Pirfenidone Increases Healing of Chronic Diabetic Foot Ulcers: A Randomized Crossover Study

Table 1

Baseline characteristics of the studied population.

Variable	Group 1; ()	Group 2; ()
Male, number (%)	13 (65)	15 (75)	0.366
Age (years)	55.9 ± 14.2	54.7 ± 11.2	0.769
BMI, kg/m^2	25.3 [23.3–30.7]	29.0 [25.8–33.4]	0.048
Systolic blood pressure, mmHg	130 [115–140]	130 [120–140]	0.859
Diastolic blood pressure, mmHg	70 [70–80]	70 [70–85]	0.318
Time from DM diagnosis, years	18.3 [14.3–28.0]	15.3 [9.6–21.0]	0.107
Glucose, mg/dL	148 [110–196]	136 [108–191]	0.988
Creatinine, mg/dL	1.2 [.99–2]	0.95 [.86–1.3]	0.059
Albuminuria, mg/24 h	277.4 [27.4–758]	87.4 [11–739.6]	0.241
A1c, %	8.2 [7.2–8.4]	8.6 [7.1–9.5]	0.184
Triglycerides, mg/dL	135.5 [109–192]	133.5 [97.5–251]	0.930
Total cholesterol, mg/dL	172 [137–178]	159 [137–183]	0.988
HDL cholesterol, mg/dL	44.2 ± 13.5	41.8 ± 8.8	0.503
LDL cholesterol, mg/dL	93.9 ± 33.2	90 ± 34.1	0.733
ALT, U/L	17 [13–23]	18 [13–30]	0.837
AST, U/L	18 [17–24]	19.5 [14–22]	0.937
Uric acid, mg/dL	6.9 ± 1.5	6.5 ± 1.7	0.480
Hemoglobin, g/dL	12.7 [11.7–13.5]	13.5 [12.2–15.4]	0.349
Hematocrit, %	38 [36–41.5]	39.9 [36.7–45.9]	0.388
Platelets, K/L	229.2 ± 54	239.2 ± 61.9	0.608
White blood cells, 10^3	7 ± 1.3	7.1 ± 1.2	0.868
ESR, mm/h	14 [5–34.5]	12 [6–32]	0.987
C-reactive protein, mg/dL	.28 [.18–.94]	.35 [.18–.93]	0.690

Data is expressed as mean ± SD or median [interquartile range]. BMI: body mass index calculated as weight in kilograms divided by the square of height in meters; DM: diabetes mellitus; A1c: glycated hemoglobin; HDL: high density lipoprotein; LDL: low density lipoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ESR: erythrocyte sedimentation rate.