Oxygenation of the Intraportally Transplanted Pancreatic Islet

Figure 6

Graphs depicting a summary of model results for calculation of fractional loss of insulin secretory capacity [FLISC (%)] with respect to external (), islet fractional viability (OCR/DNA), and diameter () and with or without thrombus formation ( μm). The critical used in the model was 5 mm Hg, which represents the best case scenario. The graph on the left (a) illustrates the change in FLISC for an islet of average diameter (150 μm) for the 3 OCR/DNA values. The graph on the right (b) illustrates the change in FLISC for an islet with average OCR/DNA (200 nmol/min/mg DNA) for 3 islet diameter values. FLISC is defined as the loss of insulin secretory capacity relative to an islet not limited by hypoxia. FLISC, fractional loss of insulin secretory capacity; , thickness of the thrombus; OCR, oxygen consumption rate; , oxygen partial pressure; , critical for insulin secretion; , external blood ; , islet radius.

(a)

(b)