Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy

Figure 1

The canonical Wnt signalling pathway implicated in diabetic nephropathy. When a WNT ligand binds to the Frizzled (FZD) and the LRP5/6 coreceptors, the Dvl protein is recruited and inhibits the binding of β-catenin, leading to an increase in cytoplasmic β-catenin levels and subsequent activation of downstream signalling targets (a). In the absence of any WNT ligand (b), β-catenin is sequestered by the Axin complex containing such proteins as GSK3-β, APC, CK1, βTrCP, and axin itself. β-catenin is then phosphorylated and ubiquitinated and enters the proteasomal degradation pathway and leading to subsequent repression of downstream signalling targets.

(a)

(b)