miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy

Table 1

Demographic characteristics of subjects.

	Normo.; ()	Micro.; ()	Macro.; ()
Age (years)	57.90 ± 1.50	59.00 ± 1.84	55.00 ± 1.81
Sex, male/female	27/3	27/3	17/3
Duration of diabetes (years)	7.08 ± 1.15	8.74 ± 1.26	8.33 ± 1.65
BMI	24.76 ± 0.61	24.26 ± 0.48	25.47 ± 0.61
SBP (mmHg)	136 ± 4.17	139.93 ± 3.22	149.8 ± 5.03
DBP (mmHg)	82.23 ± 1.94	85.67 ± 2.16	90.5 ± 3.29
HbA1C, %	9.43 ± 0.42	9.50 ± 0.34	9.47 ± 0.38
Scr (mol/L)	74.47 ± 2.72	78.87 ± 3.35	91.1 ± 8.11
Cystatin (mg/L)	0.98 ± 0.04	1.22 ± 0.08	1.44 ± 0.12
TC (mmol/L)	4.87 ± 0.16	4.75 ± 0.17	4.53 ± 0.21
TGs (mmol/L)	1.31 ± 0.09	1.67 ± 0.20	2.82 ± 0.40
HDL-C (mmol/L)	1.00 ± 0.03	0.97 ± 0.24	0.99 ± 0.26
LDL-C (mmol/L)	3.11 ± 0.16	3.08 ± 0.17	2.75 ± 0.17
eGFR (mL/min/1.73 m^2)	94.78 ± 2.86	87.45 ± 3.57	86.82 ± 5.96
UACR (mg/mmol)	0.98 ± 0.10	17.07 ± 3.44	210.02 ± 49.49
UAER (mg/24 h)	9.44 ± 0.74	145.47 ± 14.42	1742.8 ± 371.14

Data are expressed as means ± SE. Normo.: normoalbuminuria; micro.: microalbuminuria; macro.: macroalbuminuria; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1C: glycosylated hemoglobin; Scr: serum creatinine; TC: cholesterol; TGs: triglycerides; HDL-C: high-density lipoprotein-cholesterol; LDL-C: low-density lipoprotein-cholesterol; eGFR: estimated glomerular filtration rate; UACR: urinary albumin/creatinine ratio; UAER: urinary albumin excretion rate. values were calculated by Student’s -test. versus normo. group; versus micro. group.