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Journal of Diabetes Research
Volume 2016 (2016), Article ID 7965317, 10 pages
http://dx.doi.org/10.1155/2016/7965317
Research Article

Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients

1Department of Clinical Medicine, School of Nursing & Medicine, Huzhou University, Huzhou, Zhejiang 313000, China
2Department of Nursing Medicine, School of Nursing & Medicine, Huzhou University, Huzhou, Zhejiang 313000, China
3Surgery Department, Huzhou Wu Xing People’s Hospital, Huzhou, Zhejiang 313008, China
4Physical Examination Center, Zhebei Clinical Medicine Hospital, Huzhou University, Huzhou, Zhejiang 313000, China
5Endocrinology Department, Zhebei Clinical Medicine Hospital, Huzhou University, Huzhou, Zhejiang 313000, China
6Huanzhu Street Community Health Center, Huzhou, Zhejiang 313000, China

Received 12 April 2016; Accepted 5 June 2016

Academic Editor: Jixin Zhong

Copyright © 2016 Zhen Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased levels of hypersensitivity C-reactive protein (hs-CRP), interleukin (IL-4), IL-10, and tryptase in prediabetes subjects and hs-CRP, immunoglobulin E (IgE), IL-4, and IL-10 in T2DM subjects. We concluded that Hs-CRP, IgE, IL-4, IL-10, and tryptase were positively associated with prediabetes or T2DM. Further large prospective studies are warranted to assess a temporal relation between inflammatory biomarkers and incidence of prediabetes or T2DM and its associated chronic diseases.