Journal of Diabetes Research / 2016 / Article / Tab 1

Research Article

Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients

Table 1

Baseline characteristics of 560 subjects with different glucose status grouped according to fasting, postload glucose levels, and HbA1c.

VariableNGG ()PDG ()T2DMG () value

Age (years)58.13 ± 6.3759.31 ± 6.8659.37 ± 7.070.122
Sex (%, male)47.040.540.50.310
BMI (kg/m2)23.58 ± 3.1725.11 ± 3.5124.55 ± 3.15<0.001
WC (cm)79.92 ± 9.1985.00 ± 9.8983.85 ± 8.90<0.001
WHR0.84 ± 0.060.87 ± 0.050.87 ± 0.06<0.001
Smoking status (%)0.071
 Current 63.928.87.3
 Never73.019.17.9
 Past63.031.77.9
Alcohol use (in the past 12 months) (%, drinker)25.117.222.20.130
History of diabetes (%, yes)6.812.629.4<0.001
History of myocardial infarction (%, yes)0.90.92.40.493
History of high blood pressure (%, yes)15.114.018.30.689
History of stroke (%, yes)4.65.64.80.731
History of dyslipidemia (%, yes)8.76.513.50.360
Physical activity (MET/week)440.47 ± 146.79447.92 ± 151.39427.49 ± 152.150.480
Dietary intake (%, excess energy intake)74.972.173.00.800
Carbohydrate intake (%)0.740
 <55% of total energy intake56.654.950.8
 55–65% of total energy intake24.224.223.8
 >65% of total energy intake19.220.925.4
Fat intake (%)0.005
 <20% of total energy intake11.920.023.8
 20–25% of total energy intake41.138.146.8
 >25% of total energy intake47.049.129.4
Protein intake (%)0.529
 <60% of total energy intake16.911.212.7
 60–65% of total energy intake29.731.631.7
 >65% of total energy intake53.457.255.6
FPG (mmol/L)5.17 (4.94–5.34)5.97 (5.74–6.20)7.72 (7.35–8.89)<0.001
2 h OGTT (mmol/L)5.35 ± 1.087.64 ± 1.4812.16 ± 1.55<0.001
HbA1c (%)5.06 ± 0.805.20 ± 1.036.64 ± 1.64<0.001
Fasting insulin (mU/L)7.0 (6.55–7.36)7.36 (6.89–8.70)10.10 (8.54–13.7)<0.001
HOMA-IR1.60 (1.42–1.73)2.04 (1.81–2.32)3.64 (2.93–4.58)<0.001
HOMA-β84.14 (72.72–99.79)60.27 (52.46–70.64)48.67 (32.96–66.35)<0.001
SBP (mmHg)121.74 ± 20.01130.94 ± 23.61130.49 ± 18.90<0.001
DBP (mmHg)76.46 ± 9.9780.53 ± 11.2977.83 ± 8.31<0.001
TC (mmol/L)4.85 ± 0.845.00 ± 0.905.24 ± 1.120.001
TG (mmol/L)1.33 (1.04–1.94)1.72 (1.30–2.44)1.95 (1.31–3.17)<0.001
HDL-c (mmol/L)1.29 ± 0.321.20 ± 0.301.16 ± 0.28<0.001
LDL-c (mmol/L)2.85 ± 0.752.80 ± 0.922.90 ± 1.040.613
IgE (IU/L)18 (7–34)20 (7–42.5)40 (16–64)<0.001
hs-CRP (mg/L)0.5 (0.3–1.0)0.8 (0.4–2.0)1.50 (1.00–2.40)<0.001
IL-6 (ng/L)58.56 ± 12.6660.92 ± 12.8260.39 ± 10.280.117
TNF- (pg/mL)284.94 ± 61.17290.13 ± 68.22295.37 ± 57.250.326
Tryptase (ng/mL)1481.21 ± 271.441545.36 ± 291.451524.96 ± 286.650.036
IL-4 (ng/L)283.45 ± 52.50303.70 ± 56.84304.45 ± 55.87<0.001
IL-10 (ng/L)229.23 ± 46.54244.03 ± 53.34265.04 ± 40.42<0.001
Foxp3+ (pg/mL)364.22 ± 72.27367.26 ± 24.46356.18 ± 83.120.418

T2DM: type 2 diabetes mellitus; NGG: normal glucose group; PDG: prediabetes group; T2DMG: T2DM group; BMI: body mass index; WC: waist circumference; WHR: waist hip ratio; HOMA-IR: homeostasis model assessment-insulin resistance; HOMA-: homeostasis model assessment- cell function; FPG: fasting plasma glucose; 2 h OGTT: 2-hour oral glucose tolerance test; HbA1c: haemoglobin A1c; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; IgE: immunoglobulin E; hs-CRP: hypersensitivity C-reactive protein; TNF-: tumor necrosis factor; IL-6: interleukin-6; IL-4: interleukin-4; IL-10: interleukin-10; Foxp3+: forkhead/winged helix transcription factor 3+.
Variable is described using mean and standard deviation. Variable is described using median and interquartile range. , PDG compared with the NGG group; , DMG compared with the NGG group. , T2DMG compared with the PDG group.

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