Research Article

Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Figure 3

Effects of RO4987655 on (a) food intake (FI), (b) body weight (BW), (c) blood glucose, (d) glucose excursion, and (e) AUC during the oral glucose tolerance test (OGTT) in db/db mice, with RO4987655 administered for 14 days as a dietary admixture with dosages as indicated: open circle, 0 mg in 1 kg CE-2; closed triangle, 2 mg in 1 kg CE-2; open rectangle, 4 mg in 1 kg CE-2; and closed rectangle, 8 mg in 1 kg CE-2. Data are expressed as mean ± SEM, . < 0.05, < 0.01, and < 0.001 versus control (0 mg in 1 kg CE-2) at the same measurement time by parametric Dunnett’s multiple comparison test.
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