Modulation Effect of Peroxisome Proliferator-Activated Receptor Agonists on Lipid Droplet Proteins in Liver
Table 1
Metabolic phenotypes in mice before and after treatment.
Variables
Time (week)
Chow
HF
HF-P
HF-F
db/db
Body weight (g)
0
16.3 ± 1.0
17.6 ± 1.2
15.1 ± 0.3
14.6 ± 0.3
20.9 ± 0.8
8
24.4 ± 0.9
28.4 ± 0.4
25.5 ± 0.2
24.3 ± 1.1
49.9 ± 1.2
12
24.2 ± 0.6
27.2 ± 1.4
26.5 ± 0.8
25.0 ± 0.9
57.6 ± 3.2
16
23.1 ± 1.3
28.9 ± 1.3
29.2 ± 0.7
26.5 ± 0.6
20
24.4 ± 0.9
28.4 ± 1.2
29.0 ± 0.8
25.8 ± 0.8
Fasting glucose (mmol/L)
0
6.1 ± 0.2
6.2 ± 0.2
6.6 ± 0.1
6.6 ± 0.1
8.2 ± 0.3
8
6.2 ± 0.4
8.4 ± 0.4
8.1 ± 0.5
7.9 ± 0.3
15.8 ± 2.2
12
5.8 ± 0.4
8.4 ± 0.7
6.1 ± 0.3
6.1 ± 0.3
11.3 ± 1.7
16
5.4 ± 0.2
8.0 ± 1.4
6.1 ± 0.2
5.8 ± 0.2
20
6.1 ± 0.5
10.7 ± 0.4
9.2 ± 0.5
8.1 ± 0.6
Epididymal fat (g)
20 (12†)
0.32 ± 0.05
0.71 ± 0.10
0.72 ± 0.05
0.37 ± 0.05
2.15 ± 0.36
Subcutaneous fat (g)
20 (12†)
0.23 ± 0.03
0.53 ± 0.09
0.78 ± 0.03
0.25 ± 0.03
10.24 ± 1.63
Fasting serum insulin (ng/mL)
20 (12†)
0.78 ± 0.04
1.78 ± 0.23
0.91 ± 0.14
1.04 ± 0.14
4.07 ± 0.77
Serum TG (mmol/L)
20 (12†)
1.06 ± 0.15
0.92 ± 0.14
1.24 ± 0.09
1.15 ± 0.11
1.54 ± 0.15
Serum TC (mmol/L)
20 (12†)
0.77 ± 0.08
1.48 ± 0.14
0.97 ± 0.05
1.08 ± 0.06
1.89 ± 0.13
Liver TG (µmol/g)
20 (12†)
7.0 ± 0.5
12.3 ± 0.7
10.9 ± 1.1
7.5 ± 0.8
17.3 ± 3.0
Liver TC (µmol/g)
20 (12†)
6.0 ± 0.4
9.3 ± 1.4
7.2 ± 0.5
6.9 ± 0.7
14.6 ± 0.3
Data represent means ± SEM. Statistical significance of differences between groups was analyzed with one-way analysis of variance (ANOVA) followed by Bonferroni’s test. Chow: mice fed a standard chow diet; HF: mice fed a high-fat diet; HF-P: mice fed a high-fat diet and treated with pioglitazone; HF-F: mice fed a high-fat diet and treated with fenofibrate; TC: total cholesterol; TG: triglyceride. †Time for db/db. aVersus Chow, bVersus HF; , ; = 7.
