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Journal of Diabetes Research
Volume 2016, Article ID 8727590, 5 pages
http://dx.doi.org/10.1155/2016/8727590
Research Article

Hypoglycemic Activity of Aqueous Root Bark Extract Zanthoxylum chalybeum in Alloxan-Induced Diabetic Rats

1Natural Chemotherapeutics Research Institute, Ministry of Health, Kampala, Uganda
2Department of Biochemistry and Sports Science, College of Natural Sciences, Makerere University, Kampala, Uganda

Received 14 October 2015; Revised 15 January 2016; Accepted 16 February 2016

Academic Editor: Ronald G. Tilton

Copyright © 2016 Moses Solomon Agwaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Khan, G. Zaman, and R. A. Anderson, “Bay leaves improve glucose and lipid profile of people with Type 2 diabetes,” Journal of Clinical Biochemistry and Nutrition, vol. 44, no. 1, pp. 52–56, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. American Diabetes Association, “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 33, supplement 1, pp. S62–S69, 2010. View at Publisher · View at Google Scholar
  3. T. V. Fiorentino, A. Prioletta, P. Zuo, and F. Folli, “Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases,” Current Pharmaceutical Design, vol. 19, no. 32, pp. 5695–5703, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Modak, P. Dixit, J. Londhe, S. Ghaskadbi, and T. P. A. Devasagayam, “Indian herbs and herbal drugs used for the treatment of diabetes,” Journal of Clinical Biochemistry and Nutrition, vol. 40, no. 3, pp. 163–173, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Somani, S. Kasture, and A. K. Singhai, “Antidiabetic potential of Butea monosperma in rats,” Fitoterapia, vol. 77, no. 2, pp. 86–90, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. J. R. S. Tabuti, “Zanthoxylum chalybeum Engl. [Internet] record from PROTA4U,” in Plant Resources of Tropical Africa, G. H. Schmelzer and A. Gurib-Fakim, Eds., PROTA, Wageningen, The Netherlands, 2011. View at Google Scholar
  7. P. E. Ogwang, J. Nyafuono, M. S. Agwaya, F. Omujal, R. H. Tumusiime, and A. H. Kyakulaga, “Preclinical efficacy and safety of herbal formulation for management of wounds,” Journal of African Health Sciences, vol. 11, no. 3, pp. 524–529, 2011. View at Google Scholar
  8. OECD. Organization for Economic Co-Operation and Development, OECD Guidelines for the Testing of Chemicals/Section 4: Health Effects Test No. 423; Acute Oral Toxicity-Acute Toxic Class Method, OECD, Paris, France, 2014.
  9. K. Srinivasan and P. Ramarao, “Animal models in type 2 diabetes research: an overview,” Indian Journal of Medical Research, vol. 125, no. 3, pp. 451–472, 2007. View at Google Scholar · View at Scopus
  10. M. A. Ali, M. C. Sultana, B. M. Rahman, N. A. Khatune, and M. I. I. Wahed, “Antidiabetic activity of ethanolic extract of Semecarpus anacardium (linn.) Stem barks in normal and alloxan induced diabetic rats,” International Journal of Pharmaceutical Science and Research, vol. 3, no. 8, pp. 2680–2685, 2015. View at Google Scholar
  11. C. Aloke, N. Nwachukwu, E. I. Ugwuja et al., “Effects of Zanthoxylum zanthoxyloides leaves on blood glucose, lipid profile and some liver enzymes in alloxan induced diabetic rats,” International Journal of Science and Nature, vol. 3, no. 3, pp. 497–501, 2012. View at Google Scholar
  12. T. P. Singh and O. M. Singh, “Phytochemical and pharmacological profile of Zanthoxylum armatum DC.—an overview,” Indian Journal of Natural Products and Resources, vol. 2, no. 3, pp. 275–285, 2011. View at Google Scholar · View at Scopus
  13. K. Arun and M. Paridhavi, “An ethno botanical, phytochemical and pharmacological utilization of widely distributed species Zanthoxylum: a comprehensive over view,” International Journal of Pharmaceutical Invention, vol. 2, no. 1, pp. 24–35, 2012. View at Google Scholar
  14. S. Ayodhya, S. Kusum, and S. Anjali, “Hypoglycemic activity of different extracts of various herbal plants,” International Journal of Research in Ayurveda & Pharmacy, vol. 1, no. 1, pp. 212–224, 2010. View at Google Scholar
  15. A. Arya, S. C. Cheah, C. Y. Looi, H. Taha, M. R. Mustafa, and M. A. Mohd, “The methanolic fraction of Centratherum anthelminticum seed down regulates pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats,” Food and Chemical Toxicology, vol. 50, pp. 4209–4220, 2012. View at Google Scholar
  16. A. S. Nalule, J. M. Mbaria, and J. W. Kimenju, “In vitro anti-helminthic potential and phytochemical composition of ethanolic and aqueous crude extracts of Zanthoxylum chalybeum,” African Journal of Pharmacy and Pharmacology, vol. 7, no. 23, pp. 1605–1614, 2013. View at Google Scholar
  17. M. Alagammal, R. A. Agnel, and V. R. Mohan, “Anti-diabetic and anti-hyperlipidaemic effect of Polygala javana DC on alloxan induced diabetic rats,” International Research Journal of Pharmacy, vol. 3, pp. 231–234, 2012. View at Google Scholar
  18. Q.-L. Mao-Ying, A. Kavelaars, K. Krukowski et al., “The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model,” PLoS ONE, vol. 9, no. 6, Article ID e100701, 2014. View at Publisher · View at Google Scholar · View at Scopus