Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals

Figure 1

Boxplot showing the distribution of global DNA methylation across glucose tolerance status. Global DNA methylation was significantly higher in diabetic participants than in normotolerant participants (), significantly higher in screen-detected diabetes than in known diabetes (), and significantly higher in prediabetes than in normal glucose tolerance (). But there was no difference in global DNA methylation between known diabetes and normal glucose tolerance () and between known diabetes and prediabetes (); all values are adjusted for multiple comparisons. Median global DNA methylation (25th–75th percentiles): normal: 2.81 (0.68–4.62; ); prediabetes: 3.40 (1.53–5.45; ); screen-detected diabetes: 4.62 (1.71–6.77; ); known diabetes: 3.07 (0.80–4.45; ).