Journal of Diabetes Research / 2016 / Article / Tab 1

Research Article

Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals

Table 1

Characteristics according to glucose tolerance status.

CharacteristicNormotolerantPrediabetesScreen-detected diabetesKnown diabetes value

(%)283 (50.5)119 (21.2)97 (17.3)61 (10.9)
Median actual% 5mc2.83 (0.71–4.62)3.41 (1.55–5.45)4.62 (1.71–6.77)3.07 (0.80–4.45)0.0001
Women, (%)215 (76.0)98 (82.3)81 (83.5)40 (65.6)0.030
Current smoking, (%)121 (42.8)44 (37.0)35 (36.1)20 (32.8)0.363
Current drinking, (%)80 (28.3)33 (27.7)25 (25.8)12 (19.7)0.573
Age (years)49.7 (13.5)54.0 (12.0)58.0 (13.3)58.3 (11.4)<0.0001
Body mass index (kg/m2)28.7 (7.2)31.2 (7.1)32.5 (7.3)30.5 (6.6)<0.0001
Waist circumference (cm) 93 (14)99 (15)102 (16)101 (14)<0.0001
Hip circumference (cm)108 (15)112 (14)114 (15)109 (15)0.007
Waist-to-hip ratio0.86 (0.07)0.89 (0.09)0.89 (0.08)0.92 (0.08)<0.0001
Systolic blood pressure (mmHg)119 (18)122 (15)129 (21)128 (18)<0.0001
Diastolic blood pressure (mmHg)74 (11)74 (10)76 (12)75 (12)0.323
Fasting blood glucose (mmol/L)5.0 (0.7)5.7 (0.5)8.5 (3.4)11.1 (4.2)<0.0001
2-hour glucose (mmol/L)5.9 (1.0)8.6 (1.1)13.9 (5.7)NA<0.0001
HbA1c (%)5.7 (0.4)5.8 (0.4)7.1 (1.8)8.3 (1.8)<0.0001
Fasting insulin (μU/mL)6.2 (3.0–10.6)7.2 (1.9–12.7)9.3 (3.7–16.1)8.0 (2.8–12.8)0.013
2-hour insulin (μU/mL)33.9 (17.1–54.4)58.2 (26.1–97.9)56.6 (21.2–108.6)NA<0.0001
C-reactive protein (mg/L)2.8 (0.7–7.1)6.6 (1.8–12.6)6.4 (2.1–11.8)4.0 (1.3–7.6)<0.0001
Cotinine (ng/mL)10.0 (9.0–307.5)10.0 (9.0–270.2)10.0 (9.0–213.0)10.0 (9.0–125.2)0.514
Gamma-glutamyltransferase (IU/L)25.0 (17.0–36.5)29.0 (22.0–41.0)33.0 (24.0–54.0)29.5 (20.0–45.7)<0.0001
Triglycerides (mmol/L)1.1 (0.8–1.4)1.4 (1.1–1.8)1.6 (1.2–2.1)1.6 (1.2–2.2)<0.0001
HDL-cholesterol (mmol/L)1.3 (0.3)1.3 (0.3)1.3 (0.3)1.1 (0.3)0.007
LDL-cholesterol (mmol/L)3.6 (1.0)3.6 (1.0)4.0 (1.1)3.3 (1.1)0.0001
Total cholesterol (mmol/L)5.5 (1.2)5.6 (1.1)6.1 (1.3)5.3 (1.1)<0.0001

Values are count (percentages), mean (standard deviation), or median (25th–75th percentiles).

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