Research Article

Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients

Table 2

Logistic regression analysis of the association between different A1c groups and insulin resistance.

CharacteristicsModel 1 Model 2Model 3
OR (95% CI) P OR (95% CI) P OR (95% CI) P

A1c groups
 Group 11 (reference)1 (reference)1 (reference)
 Group 21.30 (0.82–2.05) 0.2640.95 (0.57–1.57) 0.8340.91 (0.54–1.53) 0.708
 Group 31.29 (0.83–2.00) 0.2661.03 (0.64–1.68) 0.8921.01 (0.61–1.68) 0.969
 Group 41.89 (1.06–3.37) 0.0321.66 (0.86–3.21) 0.1341.55 (0.76–3.17) 0.226
 Group 51.85 (1.13–3.02) 0.0142.16 (1.26–3.69) 0.0052.04 (1.16–3.61) 0.014
Female1.79 (1.22–2.63) 0.0032.30 (1.50–3.51) <0.001
Age (years)0.98 (0.96–0.99) 0.0101.00 (0.98–1.02) 0.882
BMI (kg/m2)1.13 (1.05–1.21) 0.0011.11 (1.03–1.19) 0.007
WC (cm)1.05 (1.02–1.07) <0.0011.05 (1.02–1.07) 0.001
Systolic BP (mmHg)1.00 (0.98–1.02) 0.772
Diastolic BP (mmHg)1.03 (1.01–1.06) 0.001
Cholesterol (mmol/L)0.97 (0.80–1.19) 0.787
Triglycerides (mmol/L)1.17 (1.02–1.33) 0.021
AST (U/L)1.01 (0.98–1.04) 0.646
ALT (U/L)1.02 (0.99–1.05)0.118

Model 1: unadjusted. Model 2: adjusted for age, gender, BMI, and WC. Model 3: adjusted for age, gender, BMI, WC, Systolic BP, Diastolic BP, Cholesterol, Triglycerides, AST, and ALT.