Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients
Table 2
Logistic regression analysis of the association between different A1c groups and insulin resistance.
Characteristics
Model 1
Model 2
Model 3
OR (95% CI)
P
OR (95% CI)
P
OR (95% CI)
P
A1c groups
Group 1
1 (reference)
1 (reference)
1 (reference)
Group 2
1.30 (0.82–2.05)
0.264
0.95 (0.57–1.57)
0.834
0.91 (0.54–1.53)
0.708
Group 3
1.29 (0.83–2.00)
0.266
1.03 (0.64–1.68)
0.892
1.01 (0.61–1.68)
0.969
Group 4
1.89 (1.06–3.37)
0.032
1.66 (0.86–3.21)
0.134
1.55 (0.76–3.17)
0.226
Group 5
1.85 (1.13–3.02)
0.014
2.16 (1.26–3.69)
0.005
2.04 (1.16–3.61)
0.014
Female
—
1.79 (1.22–2.63)
0.003
2.30 (1.50–3.51)
<0.001
Age (years)
—
0.98 (0.96–0.99)
0.010
1.00 (0.98–1.02)
0.882
BMI (kg/m2)
—
1.13 (1.05–1.21)
0.001
1.11 (1.03–1.19)
0.007
WC (cm)
—
1.05 (1.02–1.07)
<0.001
1.05 (1.02–1.07)
0.001
Systolic BP (mmHg)
—
—
1.00 (0.98–1.02)
0.772
Diastolic BP (mmHg)
—
—
1.03 (1.01–1.06)
0.001
Cholesterol (mmol/L)
—
—
0.97 (0.80–1.19)
0.787
Triglycerides (mmol/L)
—
—
1.17 (1.02–1.33)
0.021
AST (U/L)
—
—
1.01 (0.98–1.04)
0.646
ALT (U/L)
—
—
1.02 (0.99–1.05)
0.118
Model 1: unadjusted. Model 2: adjusted for age, gender, BMI, and WC. Model 3: adjusted for age, gender, BMI, WC, Systolic BP, Diastolic BP, Cholesterol, Triglycerides, AST, and ALT.