Identification of Candidate Tolerogenic CD8⁺ T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model

Figure 4

Pancreas histology. Mice from Figure 2(d) were examined after H + E staining of pancreases. Insulitis was assessed by measuring the volume of islet mass obscured by lymphocytic infiltration. Examples of classification of infiltration are shown in (a) and the percentage of islets with 0, 1–25, 26–50, 51–75, and >75% infiltration is shown in (b). 10–20 microscopic fields (containing at least 100 islets) were examined for each treatment group. Groups were compared to control by ANOVA with post hoc comparison. , .

(a)

(b)