A Novel Wistar Rat Model of Obesity-Related Nonalcoholic Fatty Liver Disease Induced by Sucrose-Rich Diet

Table 2

Comparison of biochemical parameters between experimental and control groups.

Time (weeks)	Groups		P value
	Experimental	Control
Glucose (mg/dL)^†
5	272.3 (±92.5)	176.2 (±27.1)	0.035
10	434.5 (±214.5)	307.2 (±121.9)	0.235
20	324.2 (±53.4)	279.4 (±133.8)	0.468
30	463.1 (±101.7)	299.8 (±78.6)	<0.001
Total cholesterol (mg/dL)^†
5	83.5 (±18.0)	72.8 (±20.6)	0.363
10	64.5 (±13.1)	73.2 (±7.9)	0.194
20	108.0 (±33.3)	85.8 (±21.0)	0.231
30	104.3 (±33.6)	80.6 (±15.0)	0.099
HDL-cholesterol (mg/dL)^‡
5	49.1 (22.9–65.3)	39.2 (22.9–64.1)	0.779
10	34.8 (23.0–52.8)	42.3 (37.7–49.7)	0.689
20	49.6 (44.0–69.5)	57.9 (56.8–63.7)	0.315
30	65.8 (51.8–75.3)	64.0 (51.1–79.4)	1.000
VLDL-cholesterol (mg/dL)^‡
5	20.5 (14.3–25.9)	13.7 (10.9–18.9)	0.149
10	17.4 (14.1–35.7)	17.9 (13.5–19.2)	0.522
20	17.1 (11.8–24.3)	11.0 (9.0–14.1)	0.083
30	26.3 (22.1–49.8)	11.0 (9.1–17.0)	<0.001
LDL-cholesterol (mg/dL)^†
5	24.8 (±21.6)	24.8 (±12.2)	1.000
10	23.7 (±26.5)	12.7 (±6.0)	0.343
20	34.6 (±22.6)	19.5 (±16.6)	0.246
30	38.4 (±18.1)	15.0 (±10.7)	0.341
Triglycerides (mg/dL)^‡
5	102.5 (71.5–129.5)	68.5 (54.5–94.3)	0.150
10	87.0 (70.5–178.3)	89.5 (67.3–95.8)	0.522
20	85.5 (58.8–121.5)	55.0 (45.0–70.5)	0.083
30	131.5 (110.5–248.8)	55.0 (45.3–85.0)	<0.001

-test for normally distributed and Mann-Whitney test for nonnormally distributed variables; ^†mean ± standard deviation; ^‡median (interquartile range).