Review Article
The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture
Figure 17
Effect of topical NTX in various vehicles on labeling index (LI) of skin epithelium. NTX was applied topically to the skin in type 1 diabetic rats or normal rats using NTX 10−4 M, NTX 10−5 M, or NTX 10−6 M in Sorenson’s phosphate buffer, lubricant, moisturizing cream, or dimethylsulfoxide. NTX applied TID topically to dorsal skin of normal rats elevated LI by 43% to 132% in any of the four vehicles compared to normal baseline. NTX applied TID topically to dorsal skin of DB rats elevated LI by 103–147% in lubricant and by 85–89% in moisturizing cream. Photomicrographs demonstrate relative frequency of DNA synthesizing cells containing label. SPB: buffered saline; DMSO: dimethylsulfoxide; KYJ: sterile lubricating jelly; MCN: moisturizing cream (derived from [64]). , , and .