Clinical Study

Comparison of the Effects of Continuous Subcutaneous Insulin Infusion and Add-On Therapy with Sitagliptin in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Table 2

Glycemic variability between the CSII and CSII + Sig groups after the suspension of continuous subcutaneous insulin infusion.

CharacteristicGroup value
CSIICSII + Sig

MAGE (mmol/L)3.98 ± 0.552.84 ± 0.92<0.01
SDBG (mmol/L)2.01 ± 0.371.42 ± 0.37<0.01
LAGE (mmol/L)6.81 ± 1.295.55 ± 1.27<0.01
MBG (mmol/L)7.95 ± 0.576.64 ± 0.37<0.01
PT10.0 (%)6.25 ± 1.481.50 ± 1.83<0.01
PT3.9 (%)2.42 ± 3.600.29 ± 0.730.04
1 h MBG
 Before breakfast (mmol/L)6.42 ± 0.456.04 ± 0.680.01
 Before lunch (mmol/L)6.68 ± 1.036.16 ± 0.660.02
 Before supper (mmol/L)6.71 ± 0.896.17 ± 0.560.01
3 h MBG
 After breakfast (mmol/L)9.78 ± 1.607.51 ± 0.64<0.01
 After lunch (mmol/L)8.78 ± 1.497.59 ± 0.56<0.01
 After supper (mmol/L)9.29 ± 1.787.50 ± 0.61<0.01

Note: MAGE: mean amplitude of glycemic excursions; SDBG: standard deviation of blood glucose; LAGE: largest amplitude of glycemic excursions; MBG: mean blood glucose; PT3.9: proportion (%) of time in hypoglycemia (<3.9 mmol/L); PT10.0: proportion (%) of time in hyperglycemia (>10 mmol/L). Independent-samples -tests were employed.