Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2017, Article ID 1310265, 7 pages
https://doi.org/10.1155/2017/1310265
Review Article

Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets

1Department of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, Romania
2Gastroenterology Department, “Sf. Spiridon” County Clinical Emergency Hospital, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, Romania
33rd Internal Medicine Clinic, “Sf. Spiridon” County Clinical Emergency Hospital, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Iasi, Romania

Correspondence should be addressed to Manuela Ciocoiu; moc.oohay@3002uiocoicm

Received 29 December 2016; Revised 2 March 2017; Accepted 9 March 2017; Published 21 March 2017

Academic Editor: Christian Trummer

Copyright © 2017 Georgiana-Emmanuela Gilca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [23 citations]

The following is the list of published articles that have cited the current article.

  • Raphael M. Singh, Tahreem Waqar, Frank C. Howarth, Ernest Adeghate, Keshore Bidasee, and Jaipaul Singh, “Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart,” Heart Failure Reviews, 2017. View at Publisher · View at Google Scholar
  • Kaviyarasi Renu, Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam, and Abilash, “Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy – a hypothesis,” Asian Pacific Journal of Tropical Biomedicine, vol. 7, no. 11, pp. 1041–1045, 2017. View at Publisher · View at Google Scholar
  • Hong Zhao, Mingzhu Tang, Meiqing Liu, and Linxi Chen, “Glycophagy: An emerging target in pathology,” Clinica Chimica Acta, vol. 484, pp. 298–303, 2018. View at Publisher · View at Google Scholar
  • Dharmender Malik, Bhagwant Rai Mittal, Ashwani Sood, Madan Parmar, Komalpreet Kaur, and Ajay Bahl, “Prognostic value of left ventricular mechanical dyssynchrony indices in long-standing type II diabetes mellitus with normal perfusion and left ventricular systolic functions on SPECT-MPI,” Journal of Nuclear Cardiology, 2018. View at Publisher · View at Google Scholar
  • Chao Ma, Huan Luo, Bing Liu, Feng Li, Carsten Tschöpe, and Xianen Fa, “Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?,” Diabetes/Metabolism Research and Reviews, pp. e3056, 2018. View at Publisher · View at Google Scholar
  • Wang Chengji, and Fan Xianjin, “Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Dharmender Malik, Bhagwant Mittal, Ashwani Sood, Madan Parmar, Gurvinder Kaur, and Ajay Bahl, “Left ventricular mechanical dyssynchrony assessment in long-standing type II diabetes mellitus patients with normal gated SPECT-MPI,” Journal of Nuclear Cardiology, 2018. View at Publisher · View at Google Scholar
  • Evangelos Oikonomou, Konstantinos Mourouzis, Petros Fountoulakis, Georgios Angelos Papamikroulis, Gerasimos Siasos, Alexis Antonopoulos, Georgia Vogiatzi, Sotiris Tsalamadris, Manolis Vavuranakis, and Dimitris Tousoulis, “Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance,” Heart Failure Reviews, 2018. View at Publisher · View at Google Scholar
  • Songyan Meng, Fan Yang, Yueqiu Wang, Ying Qin, Huimin Xian, Hui Che, and Lihong Wang, “Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF-β1/Smad signaling,” Cell Biology International, vol. 43, no. 1, pp. 65–72, 2018. View at Publisher · View at Google Scholar
  • Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, and Peter Sartipy, “Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models,” Stem Cell Reviews and Reports, 2018. View at Publisher · View at Google Scholar
  • Soheyla Khakdan, Maryam Delfan, Maryam Heydarpour Meymeh, Faranak Kazerouni, Hamid Ghaedi, Mehrnoosh Shanaki, Fatemeh Kalaki-Jouybari, Sattar Gorgani-Firuzjaee, and Ali Rahimipour, “High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats,” Archives of Physiology and Biochemistry, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Tarun Pant, Anuradha Dhanasekaran, Juan Fang, Xiaowen Bai, Zeljko J. Bosnjak, Mingyu Liang, and Zhi-Dong Ge, “Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy,” BMC Cardiovascular Disorders, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Ya-Han Huang, Po-Yuan Wu, Kuo-Ching Wen, Chien-Yih Lin, and Hsiu-Mei Chiang, “Protective effects and mechanisms of Terminalia catappa L. methenolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts,” BMC Complementary and Alternative Medicine, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Giulia Borghetti, Dirk von Lewinski, Deborah M. Eaton, Harald Sourij, Steven R. Houser, and Markus Wallner, “Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control,” Frontiers in Physiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Xiao-Yu Lyu, Li Yu, and Yu-Jun Wang, “High glucose induces myocardial cell injury through increasing reactive oxygen species production,” Asian Pacific Journal of Tropical Medicine, vol. 11, no. 1, pp. 63–67, 2018. View at Publisher · View at Google Scholar
  • Elena-Daniela Grigorescu, Cristina-Mihaela Lacatusu, Mariana Floria, Bogdan-Mircea Mihai, Ioana Cretu, and Laurentiu Sorodoc, “Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives,” Diagnostics, vol. 9, no. 3, pp. 121, 2019. View at Publisher · View at Google Scholar
  • Vivek S. Kumawat, and Ginpreet Kaur, “Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications,” European Journal of Pharmacology, pp. 172628, 2019. View at Publisher · View at Google Scholar
  • Dongjuan Wang, Longfu Jiang, Beili Feng, Nana He, Yue Zhang, and Honghua Ye, “Protective effects of glucagon‐like peptide‐1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of rapamycin complex 1/p70 ribosomal protein S6 kinase pathway in diabetes mellitus,” Journal of Diabetes Investigation, 2019. View at Publisher · View at Google Scholar
  • Manli Yu, Xinghua Shan, Yu Liu, Jiaqi Zhu, Qingxin Cao, Fan Yang, Yang Liu, Guokun Wang, and Xianxian Zhao, “RNA‐Seq analysis and functional characterization revealed lncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucose,” Journal of Cellular Biochemistry, 2019. View at Publisher · View at Google Scholar
  • Perry V. Halushka, Andrew J. Goodwin, and Marc K. Halushka, “Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers,” Annual Review of Pathology: Mechanisms of Disease, vol. 14, no. 1, pp. 211–238, 2019. View at Publisher · View at Google Scholar
  • Leilei Yin, Yingying Fang, Tao Song, Dan Lv, Zheng Wang, Li Zhu, Zihui Zhao, and Xinhua Yin, “FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC β2 pathway,” Journal of Cellular and Molecular Medicine, 2019. View at Publisher · View at Google Scholar
  • Zhenggui Wang, Jing Li, Yonggang Wang, and Quan Liu, “CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells,” Biochemical and Biophysical Research Communications, 2019. View at Publisher · View at Google Scholar
  • Miguel Alejandro Rodriguez-Ramos, “Diabetic cardiomyopathy: Five major questions with simple answers,” US Cardiology Review, vol. 13, no. 1, pp. 46–48, 2019. View at Publisher · View at Google Scholar