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Journal of Diabetes Research
Volume 2017 (2017), Article ID 1426705, 5 pages
Research Article

Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes

1Serviço de Endocrinologia do Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
2Serviço de Medicina Interna do Centro Hospitalar de São João, Porto, Portugal
3Faculdade de Medicina da Universidade do Porto, Porto, Portugal
4Hospital CUF Porto, Porto, Portugal

Correspondence should be addressed to Filipe M. Cunha; moc.liamg@ahnucrmepilif

Received 21 May 2017; Revised 8 July 2017; Accepted 10 July 2017; Published 2 August 2017

Academic Editor: Janet H. Southerland

Copyright © 2017 Filipe M. Cunha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). Diabetic patients with chronic HF seem to have higher BNP than nondiabetics. We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics. Methods. From a prospectively recruited population of acute HF patients, we selected a convenience sample. In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction. Diabetics and nondiabetics were compared. Cox-regression analysis was used to analyse the prognostic impact of diabetes. Results. We studied 328 patients, mean age: 78 years, 44.5% male. Diabetics were more often hypertensive and had ischemic HF; they had higher body mass index, lower haemoglobin, and worse renal function. Diabetics were more often discharged on ACE inhibitors/ARB, antiplatelet therapy, and statins. Neither admission nor discharge BNP values differed between diabetics and pair-matched nondiabetics. One-year mortality was also nondifferent between pairs of diabetics and nondiabetics: 44 (26.8%) and 46 (28.0%), respectively. HR for 1-year mortality in diabetics was 1.00 (95% CI: 0.82–1.24) compared with nondiabetics. Conclusions. HF patients with diabetes have similar neurohumoral activation when compared with nondiabetics. One-year mortality is also nondifferent after matching for age, gender, and systolic function.