The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Figure 4

We show the theoretical mechanism of how hyperglycemia favors the activation of several metabolic pathways that favor the production of ROS causing mitochondrial dysfunction. The beneficial action of antioxidants in the regeneration of antioxidant vitamins and the effect of flavonoids in the regulation of hyperglycemia.