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Journal of Diabetes Research
Volume 2017 (2017), Article ID 2195059, 10 pages
Review Article

The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis

1Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, China
2Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
3Department of Endocrinology, Affiliated Hospital of Nantong University, Nantong 226001, China

Correspondence should be addressed to Kui Jiang

Received 25 February 2017; Accepted 23 May 2017; Published 3 July 2017

Academic Editor: Andrea Flex

Copyright © 2017 Huiqun Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims/Introduction. To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods. A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group. The recessive model, allele model, additive model, heterozygote model, and homozygote model were utilized to investigate the association of three Hp gene variants and DR. Subgroup analysis on different severity of DR including nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted. Results. Six trials from different regions were finally included. A total of 1145 subjects containing 564 T2DM patients with retinopathy were included. The recessive model, allele model, additive model, and homozygote model results showed that Hp gene variants were not associated with DR, NPDR, and PDR. However, the heterozygote model indicated the association of Hp gene variants with DR. Conclusions. No association was found between the Hp gene variants and PDR and NPDR. More studies are required to verify these findings.