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Journal of Diabetes Research
Volume 2017 (2017), Article ID 2740372, 8 pages
Clinical Study

Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men

1Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
2Department of Endocrinology, The First People’s Hospital of Nantong, Nantong, China
3Department of Endocrinology, The First People’s Hospital of Lianyungang, Lianyungang, China
4Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an, China
5Department of Endocrinology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China
6Department of Endocrinology, Lianyungang Oriental Hospital, Lianyungang, China
7National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore
8Department of Medicine, National University of Singapore, Singapore

Correspondence should be addressed to Jian-hua Ma; moc.anihc@auhnaijam

Received 24 August 2016; Revised 29 November 2016; Accepted 28 December 2016; Published 8 February 2017

Academic Editor: Steven F. Abcouwer

Copyright © 2017 Feng-fei Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. CGM was performed 2 times before and after completion of insulin treatment. Results. CGM data showed the expected significant improvement of mean amplitude glycemic excursion (MAGE) with CSII therapy. The older patients had lower hourly glucose concentrations from 0200 to 0700 o’clock compared to the younger patients at baseline. Surprisingly, in the older patient group, the male patients had a potential risk of hypoglycemia after CSII therapy, especially during periods from 2300 to 2400 and 0400 to 0600. Conclusions. Our data suggested that older male patients with newly diagnosed T2D may have lower nocturnal glucose concentrations. This may potentially increase the risk of nocturnal hypoglycemia during CSII therapy. This study was registered with Chinese Clinical Trial Registry, number CliCTR-TRC-11001218.