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Journal of Diabetes Research
Volume 2017, Article ID 3560920, 6 pages
https://doi.org/10.1155/2017/3560920
Research Article

Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients

1Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China
2Graduate School of Peking Union Medical College, Beijing, China
3Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China
4Department of Pathophysiology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China

Correspondence should be addressed to Ping Li; moc.361@5768pl and YongTong Cao; moc.621@86gnotgnoyoac

Received 10 September 2016; Revised 2 January 2017; Accepted 29 January 2017; Published 23 February 2017

Academic Editor: Kezhong Zhang

Copyright © 2017 YongWei Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients. We studied 845 diabetic patients who were divided into DN group () and control group (). ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences () in HbA1c, creatinine, and urinary albumin between the two groups. The ApoE ε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41–3.47, and ), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%, ). The ApoE ε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50–0.97, and ), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%, ). These results suggest ApoE ε2 allele may be a risk factor; however ApoE ε4 allele may play a protective role of DN in Chinese type 2 diabetic patients.