Research Article
Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy
Table 2
Histologic classification of patients according to criteria proposed by Tervaert et al. [
7].
| (a) Patients with diabetic nephropathy (DN) |
| | Patient | K-DOQI stage (CKD-EPI) | Histologic class of DN | Interstitial fibrosis and tubular atrophy | Interstitial inflammation | Arteriolar hyalinosis | Large vessels arteriosclerosis |
| | 1 | 4 | IV | 3 | 1 | 2 | 1 | | 2 | 5 | IV | 3 | 2 | 2 | 1 | | 3 | 3 | IIa | 2 | 1 | 1 | 2 | | 4 | 5 | IV | 3 | 1 | 1 | 1 | | 5 | 3 | III | 2 | 1 | 2 | 1 | | 6 | 1 | IIa | 2 | 1 | 2 | 1 | | 7 | 3 | III | 2 | 1 | 2 | 1 | | 8 | 4 | III | 2 | 1 | 1 | 1 | | 9 | 3 | III | 3 | 2 | 2 | 1 | | 10 | 3 | IIb | 2 | 1 | 2 | 1 | | 11 | 1 | IIb | 1 | 1 | 1 | 1 | | 12 | 3 | III | 3 | 1 | 1 | 1 |
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| (b) Patients with nondiabetic nephropathy (NDN) |
| | Patient | K-DOQI stage (CKD-EPI) | Histologic diagnosis | Interstitial fibrosis and tubular atrophy | Interstitial inflammation | Arteriolar hyalinosis | Large vessels arteriosclerosis |
| | 1 | 1 | Nephroangiosclerosis | 2 | 0 | 1 | 1 | | 2 | 3 | FSGS (NOS) | 1 | 0 | 1 | 0 | | 3 | 1 | Lupus GN (V) | 2 | 0 | 0 | 0 | | 4 | 5 | Interstitial GN | 3 | 1 | 1 | 1 | | 5 | 5 | Endocapillary and extracapillary GN | 2 | 1 | 1 | 1 | | 6 | 4 | Nephroangiosclerosis | 2 | 2 | 2 | 1 | | 7 | 1 | Membranous GN II | 1 | 0 | 2 | 1 | | 8 | 1 | FSGS (perihilar) | 2 | 1 | 1 | 1 | | 9 | 2 | Membranous GN I | 2 | 0 | 1 | 1 | | 10 | 2 | Membranous GN II | 1 | 0 | 1 | 1 | | 11 | 3 | FSGS (NOS) | 2 | 2 | 2 | 1 |
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