Rapid Detection of the mt3243A > G Mutation Using Urine Sediment in Elderly Chinese Type 2 Diabetic Patients
Table 2
The biochemical and clinical characteristics of two patients with T2DM carrying the mt3243 A > G mutation.
Clinical and biochemical characteristics
Patient 1 (F1955II-1)
Patient 2 (F1956II-1)
Age (years)
74
72
Age of diagnosis (years)
56
57
Sex (M/F)
M
M
BMI (kg/m2)
23.7
19.5
Blood pressure (mmHg)
SBP
124
108
DBP
68
68
HbA1c (%)
5.9
7.9
Fasting plasma glucose (mmol/L)
5.24
6.92
2 h postprandial plasma glucose (mmol/L)
10.25
12.40
Fasting C-peptide (ng/mL)
0.64
1.21
2 h postprandial C-peptide (ng/mL)
2.30
2.89
GAD-Ab (U/mL)
0.00
0.00
IA2-Ab (U/mL)
0.00
0.00
Triglyceride (mmol/L)
0.61
1.09
Total cholesterol (mmol/L)
3.48
4.11
HDL-c (mmol/L)
1.65
0.99
LDL-c (mmol/L)
1.61
2.50
Urine ketones
Negative
Negative
ACR (μg/mg)
9.23
152.55
Creatinine kinase (U/L)
104
22
Treatment
Oral drugs, insulin
Oral drugs
Thyroid disease
No
No
Self-reported hearing impairment
No
Yes
Audiogram
Bilateral sensorineural hearing loss
NA
Neurological involvement
Hypomnesia
No
MRI
Hypointensity on T1-weighted images and hyperintensity on T2-weighted images of the bilateral frontal lobe, bilateral parietal lobe, basal ganglia, and corona radiata
NA
Retinal OCT
IS/OS disruption
NA
BMI: body mass index; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; ACR: urinary albumin to creatinine ratio; GAD-Ab: glutamic acid decarboxylase (GAD-Ab); IA2-Ab: islet antigen 2 (IA2-Ab); NA: not available; OCT: optical coherence tomography; IS/OS: inner/outer segment.
