A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans

Figure 2

Effect of 9-phenanthrol on GLP-1-induced insulin secretion from isolated rat islets of Langerhans. Insulin secretion was studied in batch incubations where groups of three islets were incubated for 1 hour in 10 mM glucose or 10 mM glucose +50 nM GLP-1, in the presence of different concentrations of 9-phenanthrol, as indicated at the bottom of the figure. In (a), insulin secretion is expressed as μU/islet/hour and in (b), insulin secretion is expressed as percent of total insulin content per hour. (one-way ANOVA).

(a)

(b)