High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Table 4

Correlation coefficients for the associations between AGEs and clinical parameters.

T2DM ()
Index	CEL		CML		MG-H1
	HbA1c	−0.43	NS	−0.10	NS	−0.11	NS
IGI	−0.31	NS	−0.39	NS	−0.30	NS
IRI-AUC	−0.27	NS	−0.53	<0.05	−0.20	NS
HOMA-%B	−0.14	NS	−0.63	<0.05	0.01	NS
HOMA-IR	−0.13	NS	−0.47	NS	−0.04	NS
ISI	0.26	NS	0.72	<0.01	−0.04	NS
GDR	0.31	NS	0.13	NS	0.15	NS
Non-DM ()
Index	CEL		CML		MG-H1
	HbA1c	−0.03	NS	−0.10	NS	−0.05	NS
IGI	0.14	NS	0.26	NS	−0.03	NS
IRI-AUC	0.10	NS	0.24	NS	−0.18	NS
HOMA-%B	0.11	NS	0.05	NS	−0.29	NS
HOMA-IR	0.04	NS	−0.03	NS	−0.12	NS
ISI	−0.12	NS	−0.24	NS	−0.12	NS
GDR	0.16	NS	0.12	NS	0.03	NS

Correlation coefficients were determined using Pearson’s product moment correlation coefficient test. AGEs: advanced glycation end products; CEL: carboxyethyllysine; CML: carboxymethyllysine; GDR: glucose disposal rate; HOMA-%B: homeostasis model assessment of beta cell function; HOMA-IR: homeostasis model assessment for insulin resistance; IGI: insulinogenic index; IRI-AUC: immunoreactive insulin area under the curve; ISI: insulin sensitivity index; MG-H1: methyl-glyoxal-hydro-imidazolone; Non-DM: nondiabetic study participants; T2DM: study participants with type 2 diabetes mellitus; NS: not significant.