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Journal of Diabetes Research
Volume 2017 (2017), Article ID 5837804, 11 pages
Review Article

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols

Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, China

Correspondence should be addressed to Keping Chen

Received 23 February 2017; Revised 5 May 2017; Accepted 4 June 2017; Published 3 July 2017

Academic Editor: Andrea Tura

Copyright © 2017 Qi Ge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11.4%, the treatment rate is 48.2%, and the mortality rate is 2.7% worldwide. Comprehensive and effective control of diabetes, as well as the use of insulin, requires further study to develop additional treatment options. Here, we reviewed the current reprogramming of somatic cells using specific factors to induced pluripotent stem (iPS) cells capable of repairing islet β cell damage in diabetes patients to treat patients with type 1 diabetes mellitus. We also discuss the shortcomings associated with clinical use of iPS cells. Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes.