Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

Table 1

Characteristics of T2DM in ischemic stroke cases and control group.

Variables	Ischemic stroke ()	Control ()
Age, y	66.0 (60.0, 74.0)	62.0 (55.0, 69.0)	<.001
Sex, male (%)	53.8 (127/236)	61.8 (241/390)	.054
BMI, Kg/m^2	25.7 (23.5, 28.3)	25.5 (23.5, 28.0)	.960
Duration of diabetes, y	16.0 (10.0, 20.5)	16.0 (12.0, 20.0)	.111
History of hypertension (%)	75.4 (178/236)	58.2 (227/390)	<.001
Current smoking (%)	30.9 (73/236)	25.4 (99/390)	.140
SBP (mmHg)	134.5 (120.0, 146.0)	130.0 (120.0, 143.0)	.014
DBP (mmHg)	80.0 (70.0, 81.0)	80.0 (72.0, 80.0)	.879
A1C (%)	7.7 (6.7, 9.4)	7.9 (6.8, 9.2)	.668
Hcy (mol/L)	12.6 (10.3, 15.7)	12.2 (9.9, 14.4)	.073
TC (mmol/L)	4.09 (3.35, 4.85)	4.19 (3.55, 4.85)	.306
HDL-C (mmol/L)	1.00 (0.83, 1.22)	1.00 (0.84, 1.24)	.825
LDL-C (mmol/L)	2.25 (1.83, 2.89)	2.39 (1.87, 2.96)	.212
TG (mmol/L)	1.49 (1.07, 2.09)	1.54 (1.08, 2.38)	.263

A1C: hemoglobin A1C; BMI, body mass index; DBP, diastolic blood pressure; Hcy, homocysteine; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride.
Data are shown as median (interquartile range) or %.