Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

Table 5

Association of EPHX2 G860A with risk of ischemic stroke in different Hcy level groups.

Hcy level (mol/L)	Genotype	Unadjusted		Adjusted		Adjusted
		OR (95% CI)		OR (95% CI)		OR (95% CI)
Low: 4.29–10.7; ()	Additive	0.45 (0.27–0.75)	.002	0.45 (0.27–0.76)	.003	0.43 (0.25–0.75)	.003
	Recessive	0.11 (0.01–0.87)	.035	0.10 (0.01–0.81)	.031	0.09 (0.01–0.79)	.030
	Dominant	0.44 (0.24–0.81)	.008	0.45 (0.25–0.83)	.011	0.43 (0.23–0.82)	.011
Medium: 10.74–13.71; ()	Additive	1.16 (0.73–1.84)	.528	1.15 (0.71–1.86)	.579	1.15 (0.69–1.92)	.584
	Recessive	2.33 (0.75–7.22)	.142	2.52 (0.78–8.16)	.124	2.61 (0.74–9.18)	.135
	Dominant	1.01 (0.57–1.80)	.964	0.97 (0.54–1.77)	.931	0.97 (0.51–1.84)	.936
High: 13.73–53.99; ()	Additive	0.69 (0.43–1.11)	.127	0.70 (0.43–1.14)	.152	0.69 (0.42–1.14)	.146
	Recessive	0.86 (0.23–3.14)	.817	0.90 (0.25–3.32)	.879	0.84 (0.21–3.29)	.798
	Dominant	0.62 (0.36–1.38)	.088	0.63 (0.36–1.10)	.102	0.62 (0.35–1.11)	.108

Hcy, homocysteine.
Adjusted for age and sex.
Adjusted for age, sex, BMI, history of hypertension, TC, TG, and HDL-C.