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Journal of Diabetes Research
Volume 2017, Article ID 7125760, 6 pages
Research Article

The Relationship between Cardiovascular Autonomic Dysfunction and Ocular Abnormality in Chinese T2DM

1Department of Endocrinology, The 306th Teaching Hospital of People’s Liberation Army, Peking University, Beijing, China
2Department of Endocrinology, The 306th Hospital of People’s Liberation Army, Beijing, China

Correspondence should be addressed to Yanjun Liu; ten.haey@lnujnay

Received 5 October 2016; Revised 14 February 2017; Accepted 26 March 2017; Published 1 June 2017

Academic Editor: Ruozhi Zhao

Copyright © 2017 Dandan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This study aims to explore the relationship between autonomic nerve dysfunction—assessed by cardiovascular autonomic neuropathy risk score (CAN-RS)—and ocular abnormality in Chinese type 2 diabetes mellitus (T2DM). Method. This is a cross-sectional study. A total of 335 subjects with T2DM were enrolled. The state of visual acuity, the lens, the vitreous, and the fundus were tested by professional ophthalmic instruments. The electrochemical skin conductance (ESC) of the hands and feet was measured by SUDOSCAN, from which a cardiovascular autonomic neuropathy risk score (CAN-RS) was calculated. Receiver operating characteristic (ROC) curves were drawn to evaluate the feasibility and accuracy of CAN-RS in diabetic oculopathy screening. Results. Abnormalities of the lens, vitreous, and fundus accounted for 7.8%, 5.1%, and 9.9%, respectively, in this study. The means of hands and feet ESC were higher than 60 μS, and CAN-RS was 33.1 ± 14.8%. In logistic regression analysis, CAN-RS was positively associated with lens (OR = 1.055, ) and vitreous (OR = 1.044, ) abnormality. The area under ROC to detect lens and vitreous abnormality was 0.713 and 0.725, respectively. Conclusion. CAN-RS, a cardiac autonomic nerve dysfunction index calculated by SUDOSCAN, may be a promising index for lens and vitreous abnormality screening in T2DM patients. Further studies are needed to confirm the conclusion.