Journal of Diabetes Research / 2017 / Article / Tab 2 / Review Article
MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance Table 2 miRNAs related to the Slc2a4 /GLUT4 expression in insulin resistance.
Species/tissue Description Reference miR-23a Dog/skeletal muscle Downregulated after loss of weight, together with decreased Slc2a4 mRNA Uribe et al. [106 ] miR-29c-3p Mouse/heart Upregulated in heart of obese mice, together with decreased GLUT4 Guedes et al. [121 ] miR-29a-3p Rat and mouse/ Upregulated in muscle of rats with intrauterine growth restriction; overexpression in C2C12 myocyte decreased GLUT4 Zhou et al. [118 ] miR-93-5p Human/adipose Upregulated in adipose tissue of women with PCOS and/or IR; overexpression in adipocyte decreased GLUT4 Chen et al. [111 ] miR-106b-5p Rat/skeletal muscle Upregulated in muscle of rats with T2DM; overexpression in L6 myocyte decreased GLUT4 and glucose uptake Zhou et al. [114 ] miR-107 Dog/skeletal muscle Downregulated after loss of weight, together with decreased Slc2a4 mRNA Uribe et al. [106 ] miR-133a/b-3p Rat/heart Overexpression in cardiomyocyte decreased GLUT4 and insulin-stimulated glucose uptake Horie et al. [116 ] miR-222-3p Human/adipose Upregulated in adipose tissue of women with GDM; overexpression in adipocyte decreased Slc2a4 mRNA Shi et al. [115 ] miR-223-3p Human/adipose Upregulated in adipose tissue of women with IR; cell overexpression decreased GLUT4 and glucose uptake Chuang et al. [112 ] miR-223-3p Human and rat/heart Upregulated in heart of humans with T2DM; overexpression in rat cardiomyocyte increased GLUT4 Lu et al. [113 ]
