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Journal of Diabetes Research
Volume 2017, Article ID 7526919, 7 pages
https://doi.org/10.1155/2017/7526919
Research Article

NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus

1Department of Endocrinology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
2Diabetes Centre, Department of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, Athens, Greece
3Department of Clinical Biochemistry, Aghia Sophia Children’s Hospital, Athens, Greece

Correspondence should be addressed to Nektaria Papadopoulou-Marketou; moc.liamg@airatkenuoluopodapap

Received 1 September 2016; Accepted 3 April 2017; Published 23 May 2017

Academic Editor: Feng Wang

Copyright © 2017 Nektaria Papadopoulou-Marketou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups ( and , resp.) and SAP z-score () (group A) and negatively with eGFR in both groups ( and , resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range.